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Lukens JR, Gross JM, Kanneganti TD. IL-1 family cytokines trigger sterile inflammatory disease. Front Immunol. 2012;3:315doi: 10.3389/fimmu.2012.00315.
Lukens, J. R., Gross, J. M., & Kanneganti, T. D. (2012). IL-1 family cytokines trigger sterile inflammatory disease. Frontiers in immunology, 3315. https://doi.org/10.3389/fimmu.2012.00315
Lukens, John R, et al. "IL-1 family cytokines trigger sterile inflammatory disease." Frontiers in immunology vol. 3 (2012): 315. doi: https://doi.org/10.3389/fimmu.2012.00315
Lukens JR, Gross JM, Kanneganti TD. IL-1 family cytokines trigger sterile inflammatory disease. Front Immunol. 2012 Oct 09;3:315. doi: 10.3389/fimmu.2012.00315. eCollection 2012. PMID: 23087690; PMCID: PMC3466588.
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Front Immunol. 2012 Oct 09;3:315. doi: 10.3389/fimmu.2012.00315. eCollection 2012.

IL-1 family cytokines trigger sterile inflammatory disease.

Frontiers in immunology

John R Lukens, Jordan M Gross, Thirumala-Devi Kanneganti

Affiliations

  1. Department of Immunology, St. Jude Children's Research Hospital Memphis, TN, USA.

PMID: 23087690 PMCID: PMC3466588 DOI: 10.3389/fimmu.2012.00315

Abstract

Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however, in comparison, less is known about the regulation of inflammation in sterile settings. Over the past decade non-communicable chronic diseases that are potentiated by sterile inflammation have replaced infectious diseases as the major threat to global human health. Thus, improved understanding of the sterile inflammatory process has emerged as one of the most important areas of biomedical investigation during our time. In this review we highlight the central role that interleukin-1 family cytokines play in sterile inflammatory diseases.

Keywords: IL-1; IL-18; IL-33; NLRP3; Sterile inflammation; autoinflammatory disease; caspase-1; inflammasome

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