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Lin LW, Kuo YH, Hseu YC, et al. Osthole Improves Spatial Memory Deficits in Rats via Hippocampal α 1-Adrenergic and D 1 /D 2 Receptors. Evid Based Complement Alternat Med. 2013;2013:273682doi: 10.1155/2013/273682.
Lin, L. W., Kuo, Y. H., Hseu, Y. C., Tsai, C. W., Hsieh, M. T., Chen, S. C., & Wu, C. R. (2013). Osthole Improves Spatial Memory Deficits in Rats via Hippocampal α 1-Adrenergic and D 1 /D 2 Receptors. Evidence-based complementary and alternative medicine : eCAM, 2013273682. https://doi.org/10.1155/2013/273682
Lin, Li-Wei, et al. "Osthole Improves Spatial Memory Deficits in Rats via Hippocampal α 1-Adrenergic and D 1 /D 2 Receptors." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 273682. doi: https://doi.org/10.1155/2013/273682
Lin LW, Kuo YH, Hseu YC, Tsai CW, Hsieh MT, Chen SC, Wu CR. Osthole Improves Spatial Memory Deficits in Rats via Hippocampal α 1-Adrenergic and D 1 /D 2 Receptors. Evid Based Complement Alternat Med. 2013;2013:273682. doi: 10.1155/2013/273682. Epub 2013 Feb 26. PMID: 23533468; PMCID: PMC3600333.
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Evid Based Complement Alternat Med. 2013;2013:273682. doi: 10.1155/2013/273682. Epub 2013 Feb 26.

Osthole Improves Spatial Memory Deficits in Rats via Hippocampal α 1-Adrenergic and D 1 /D 2 Receptors.

Evidence-based complementary and alternative medicine : eCAM

Li-Wei Lin, Yueh-Hsiung Kuo, You Cheng Hseu, Chia-Wen Tsai, Ming-Tsuen Hsieh, Shiu Ching Chen, Chi-Rei Wu

Affiliations

  1. The School of Chinese Medicines for Post-Baccalaureate, I-Shou University, No.8, Yida Road, Yanchao Township, Kaohsiung County 82445, Taiwan.

PMID: 23533468 PMCID: PMC3600333 DOI: 10.1155/2013/273682

Abstract

The present study evaluated the effect of osthole, an active ingredient isolated from Cnidium monnieri L. Cusson, on spatial memory deficits caused by central neurotoxins using the Morris water maze in rats. The involvement of catecholaminergic receptors on the memory-enhancing effect of osthole in rat hippocampus was further investigated by intrahippocampal injection of catecholaminergic receptor antagonists. Intracisternal injection of osthole (10  μ g/brain) improved the spatial performance and working memory impairments caused by the catecholaminergic neurotoxin 6-hydroxydopamine. No significant differences in swimming speeds were observed among sham, neurotoxin-induced, and osthole-treated groups. Intracisternal osthole injection also attenuated the spatial performance and working memory impairments caused by the α 1 receptor antagonist phenoxybenzamine, the D1 receptor antagonist SCH 23390, and the D2 receptor antagonist sulpiride. Therefore, we demonstrated that the effect of osthole on improving spatial memory deficits may be related to the activation of hippocampal α 1 and D1/D2 receptors.

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