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Chen P, Yu C, Wu W, et al. Serolological Profile Among HBsAg-Positive Infections in Southeast China: A Community-Based Study. Hepat Mon. 2013;13(1):e7604doi: 10.5812/hepatmon.7604.
Chen, P., Yu, C., Wu, W., Wang, J., Ruan, B., Ren, J., Yang, S., Xu, K., Yu, L., & Li, L. (2013). Serolological Profile Among HBsAg-Positive Infections in Southeast China: A Community-Based Study. Hepatitis monthly, 13(1), e7604. https://doi.org/10.5812/hepatmon.7604
Chen, Ping, et al. "Serolological Profile Among HBsAg-Positive Infections in Southeast China: A Community-Based Study." Hepatitis monthly vol. 13,1 (2013): e7604. doi: https://doi.org/10.5812/hepatmon.7604
Chen P, Yu C, Wu W, Wang J, Ruan B, Ren J, Yang S, Xu K, Yu L, Li L. Serolological Profile Among HBsAg-Positive Infections in Southeast China: A Community-Based Study. Hepat Mon. 2013 Jan;13(1):e7604. doi: 10.5812/hepatmon.7604. Epub 2013 Jan 23. PMID: 23483608; PMCID: PMC3589882.
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Hepat Mon. 2013 Jan;13(1):e7604. doi: 10.5812/hepatmon.7604. Epub 2013 Jan 23.

Serolological Profile Among HBsAg-Positive Infections in Southeast China: A Community-Based Study.

Hepatitis monthly

Ping Chen, Chengbo Yu, Wei Wu, Jinghua Wang, Bing Ruan, Jingjing Ren, Shigui Yang, Kaijin Xu, Liang Yu, Lanjuan Li

Affiliations

  1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

PMID: 23483608 PMCID: PMC3589882 DOI: 10.5812/hepatmon.7604

Abstract

BACKGROUND: Hepatitis B virus (HBV) infection has remained a significant public health problem. Generating a large-scale, community-based profile of HBV infection in China is essential to prevention of the disease.

OBJECTIVES: The current study was designed to investigate HBV-infected individuals at the community level and determine the age distribution, hepatitis B e antigen (HBeAg) positivity and its related risk factors, relationship among serological markers.

PATIENTS AND METHODS: A cross-sectional, community-based survey was carried out without age restriction, in 12 communities of two counties. The study population was selected by random multistage cluster sampling. Serological samples and demographic information were collected from 8439 HB surface antigen (HBsAg)-positive individuals.

RESULTS: The constituent ratio of individuals with HBsAg-positive infections was lowest among persons aged < 20 years (0.4%) and the highest among persons aged 40-49 years (33.2%). The HBeAg-positive rate among infected individuals was 18.5%, and the constituent ratio decreased with increasing of age. The HBeAg-positive rate in males (21.9%) was significantly higher than in females (14.7%), and was higher among coastland inhabitants (22.9%) than among plains inhabitants (12.9%). Among the 1561 HBeAg-positive individuals, 91.0% were HBV DNA-positive. However, of the 6878 HBeAg-negative individuals, only 45.4% were HBV DNA-positive, and the HBeAg-positive rate was significantly different at different levels of HBV DNA expression. The proportion of detectable HBV DNA levels was significantly higher in individuals with elevated ALT, compared to those with normal ALT, regardless of HBeAg-positivity.

CONCLUSIONS: The HBV prevalence remained high in the > 20 age group. The positivity of HBeAg was related to age, region, and sex. Testing HBeAg and serum ALT levels were effective ways to assess HBV infectiousness in community-level hospitals in China.

Keywords: China; Hepatitis B; Hepatitis B e Antigens; Residence Characteristics; Serologic Tests

References

  1. Epidemiol Infect. 2003 Aug;131(1):757-70 - PubMed
  2. World J Gastroenterol. 2011 Oct 14;17(38):4258-70 - PubMed
  3. Bangladesh Med Res Counc Bull. 2008 Aug;34(2):39-43 - PubMed
  4. World J Gastroenterol. 2011 Nov 28;17(44):4853-7 - PubMed
  5. Lancet. 2009 Feb 14;373(9663):582-92 - PubMed
  6. Liver Int. 2009 Jan;29 Suppl 1:100-7 - PubMed
  7. Ann Intern Med. 2001 Nov 6;135(9):759-68 - PubMed
  8. Hepatology. 2002 Jun;35(6):1522-7 - PubMed
  9. Gastroenterology. 1987 Jun;92(6):1839-43 - PubMed
  10. Presse Med. 2006 Feb;35(2 Pt 2):304-7 - PubMed
  11. J Hepatol. 1996 Jun;24(6):680-5 - PubMed
  12. N Engl J Med. 2002 Jul 18;347(3):168-74 - PubMed
  13. Southeast Asian J Trop Med Public Health. 2002 Mar;33(1):110-7 - PubMed
  14. Lancet. 1989 Sep 9;2(8663):588-91 - PubMed
  15. J Med Virol. 2009 Dec;81(12):1999-2006 - PubMed
  16. Vaccine. 2009 Nov 5;27(47):6550-7 - PubMed
  17. Eur J Gastroenterol Hepatol. 2011 Aug;23(8):695-700 - PubMed
  18. Hepatol Int. 2008 Dec;2(4):478-85 - PubMed
  19. Hepatology. 2000 Mar;31(3):763-8 - PubMed
  20. J Gastroenterol Hepatol. 2003 Mar;18(3):246-52 - PubMed

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