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Vosooghi M, Yahyavi H, Divsalar K, et al. Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone. Daru. 2013;21(1):34doi: 10.1186/2008-2231-21-34.
Vosooghi, M., Yahyavi, H., Divsalar, K., Shamsa, H., Kheirollahi, A., Safavi, M., Ardestani, S. K., Sadeghi-Neshat, S., Mohammadhosseini, N., Edraki, N., Khoshneviszadeh, M., Shafiee, A., & Foroumadi, A. (2013). Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 21(1), 34. https://doi.org/10.1186/2008-2231-21-34
Vosooghi, Mohsen, et al. "Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone." Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences vol. 21,1 (2013): 34. doi: https://doi.org/10.1186/2008-2231-21-34
Vosooghi M, Yahyavi H, Divsalar K, Shamsa H, Kheirollahi A, Safavi M, Ardestani SK, Sadeghi-Neshat S, Mohammadhosseini N, Edraki N, Khoshneviszadeh M, Shafiee A, Foroumadi A. Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone. Daru. 2013 May 01;21(1):34. doi: 10.1186/2008-2231-21-34. PMID: 23635011; PMCID: PMC3673839.
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Daru. 2013 May 01;21(1):34. doi: 10.1186/2008-2231-21-34.

Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Mohsen Vosooghi, Hoda Yahyavi, Kouros Divsalar, Hashem Shamsa, Asma Kheirollahi, Maliheh Safavi, Sussan Kabudanian Ardestani, Sareh Sadeghi-Neshat, Negar Mohammadhosseini, Najmeh Edraki, Mehdi Khoshneviszadeh, Abbas Shafiee, Alireza Foroumadi

Affiliations

  1. Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. [email protected].

PMID: 23635011 PMCID: PMC3673839 DOI: 10.1186/2008-2231-21-34

Abstract

BACKGROUND AND THE PURPOSE OF THE STUDY: Modified androsterone derivatives are class of steroidal compounds with potential anticancer properties. Various steroidal derivatives containing substitution at position 16 have shown diversified pharmacological activities. In the present study, a new series of cytotoxic 16-(substituted benzylidene) derivatives of dehydroepiandrosterone (DHEA) were synthesized and evaluated against three different cancer cell lines.

METHODS: The cytotoxic 16-(substituted benzylidene) derivatives of DHEA were synthesized via aldol condensation of DHEA with corresponding benzaldehyde derivatives. The cytotoxic activity of synthesized derivatives was evaluated against three different cancer cells including KB, T47D and SK-N-MC cell lines by MTT reduction colorimetric assay.

RESULTS: The results indicated that 16-(substituted benzylidene) derivatives of DHEA could be served as a potent anti-cancer agent. The 3-cholro benzylidene derivatives of DHEA was the most potent synthesized derivative especially against KB and T47D cell lines (IC50 values were 0.6 and 1.7 μM; respectively).

CONCLUSION: The cytotoxic potential of novel benzylidene derivatives of DHEA is mainly attributed to the position and nature of the substituted group on the benzylidene pendant.

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