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Brabez N, Saunders K, Nguyen KL, et al. Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. ACS Med Chem Lett. 2012;4(1):98-102doi: 10.1021/ml300312b.
Brabez, N., Saunders, K., Nguyen, K. L., Jayasundera, T. B., Weber, C., Lynch, R. M., Chassaing, G., Lavielle, S., & Hruby, V. J. (2013). Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. ACS medicinal chemistry letters, 4(1), 98-102. https://doi.org/10.1021/ml300312b
Brabez, Nabila, et al. "Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting." ACS medicinal chemistry letters vol. 4,1 (2013): 98-102. doi: https://doi.org/10.1021/ml300312b
Brabez N, Saunders K, Nguyen KL, Jayasundera TB, Weber C, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. ACS Med Chem Lett. 2013 Jan 01;4(1):98-102. doi: 10.1021/ml300312b. Epub 2012 Nov 24. PMID: 23524643; PMCID: PMC3601667.
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ACS Med Chem Lett. 2013 Jan 01;4(1):98-102. doi: 10.1021/ml300312b. Epub 2012 Nov 24.

Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting.

ACS medicinal chemistry letters

Nabila Brabez, Kara Saunders, Kevin L Nguyen, Thanuja B M Jayasundera, Craig Weber, Ronald M Lynch, Gerard Chassaing, Solange Lavielle, Victor J Hruby

Affiliations

  1. UPMC Paris 06, UMR 7203, Laboratoire des BioMolécules, Université P. et M. Curie, 75005 Paris France ; CNRS, UMR 7203, France ; ENS, UMR 7203, Département de Chimie, Ecole Normale Supérieure, 75005 Paris France ; University of Arizona, Department of Chemistry and Biochemistry, Tucson, AZ 85721, USA.

PMID: 23524643 PMCID: PMC3601667 DOI: 10.1021/ml300312b

Abstract

In order to develop agents for early detection and selective treatment of melanomas, high affinity and high specificity molecular tools are required. Enhanced specificity may be obtained by simultaneously binding to multiple cell surface targets

Keywords: Multivalent interactions; cancer; delivery; dendrimers; melanoma; multimers; peptides; targeted therapy

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