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Yang BL, Wu S, Wu X, et al. Effect of shunting of collateral flow into the venous system on arteriogenesis and angiogenesis in rabbit hind limb. Acta Histochem Cytochem. 2013;46(1):1-10doi: 10.1267/ahc.12025.
Yang, B. L., Wu, S., Wu, X., Li, M. B., Zhu, W., Guan, Y., Liu, L. H., Luo, M. Y., Cai, W. J., Schaper, J., & Schaper, W. (2013). Effect of shunting of collateral flow into the venous system on arteriogenesis and angiogenesis in rabbit hind limb. Acta histochemica et cytochemica, 46(1), 1-10. https://doi.org/10.1267/ahc.12025
Yang, Bao-Lin, et al. "Effect of shunting of collateral flow into the venous system on arteriogenesis and angiogenesis in rabbit hind limb." Acta histochemica et cytochemica vol. 46,1 (2013): 1-10. doi: https://doi.org/10.1267/ahc.12025
Yang BL, Wu S, Wu X, Li MB, Zhu W, Guan Y, Liu LH, Luo MY, Cai WJ, Schaper J, Schaper W. Effect of shunting of collateral flow into the venous system on arteriogenesis and angiogenesis in rabbit hind limb. Acta Histochem Cytochem. 2013 Feb 28;46(1):1-10. doi: 10.1267/ahc.12025. Epub 2013 Jan 11. PMID: 23554534; PMCID: PMC3596601.
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Acta Histochem Cytochem. 2013 Feb 28;46(1):1-10. doi: 10.1267/ahc.12025. Epub 2013 Jan 11.

Effect of shunting of collateral flow into the venous system on arteriogenesis and angiogenesis in rabbit hind limb.

Acta histochemica et cytochemica

Bao-Lin Yang, Song Wu, Xiaoqiong Wu, Ming Bo Li, Wu Zhu, Yinglu Guan, Li-Hua Liu, Ming-Ying Luo, Wei-Jun Cai, Jutta Schaper, Wolfgang Schaper

Affiliations

  1. Department of Histology & Embryology, School of Basic Medicine, Central South University, Changsha, 410078, Hunan, P.R. China ; Department of Orthopedics, The 3rd Xiangya Hospital, Central South University, Changsha, 410078, Hunan, P.R. China.

PMID: 23554534 PMCID: PMC3596601 DOI: 10.1267/ahc.12025

Abstract

The aim of this study was to characterize the vascular remodeling in the external iliac artery (EIA) and the lower leg muscles in a rabbit shunt model created between the distal stump of the occluded femoral artery and the accompanying vein. Histology and immunoconfocal microscopy were used in this study. We found that: 1) both endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (P-eNOS) proteins were significantly increased in the shunt-side EIA; 2) matrix metalloproteinase-2 (MMP-2) expression was 5.5 times in shunt side EIA over that in normal EIA; 3) intercellular adhension molecule-1 (ICAM-1) expression was strongly induced in endothelial cells (EC) and vascular adhension molecule-1 (VCAM-1) expression was significantly increased in both EC and the adventitia of the shunt-side EIA; 4) augmentation of cell proliferation and extracellular proteolysis by macrophage infiltration was observed in shunt-side EIA; 5) cell proliferation was active in shunt side EIA, but quiet in shunt side lower leg's arterial vessels; 6) capillary density in shunt side lower leg muscles was 2 times over that in normal side. In conclusion, our data demonstrate the paradigm that the power of shear stress takes the reins in arteriogenesis, whereas ischemia in angiogenesis, but not in arteriogenesis.

Keywords: angiogenesis; arteriogenesis; extracelluar proteolysis; macrophages; shear stress

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