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Abdulla A, Zhao X, Yang F. Natural Polyphenols Inhibit Lysine-Specific Demethylase-1 . J Biochem Pharmacol Res. 2013;1(1):56-63
Abdulla, A., Zhao, X., & Yang, F. (2013). Natural Polyphenols Inhibit Lysine-Specific Demethylase-1 . Journal of biochemical and pharmacological research, 1(1), 56-63.
Abdulla, Arian, et al. "Natural Polyphenols Inhibit Lysine-Specific Demethylase-1 ." Journal of biochemical and pharmacological research vol. 1,1 (2013): 56-63.
Abdulla A, Zhao X, Yang F. Natural Polyphenols Inhibit Lysine-Specific Demethylase-1 . J Biochem Pharmacol Res. 2013 Mar 01;1(1):56-63. PMID: 23662249; PMCID: PMC3646376.
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J Biochem Pharmacol Res. 2013 Mar 01;1(1):56-63.

Natural Polyphenols Inhibit Lysine-Specific Demethylase-1 .

Journal of biochemical and pharmacological research

Arian Abdulla, Xiaoping Zhao, Fajun Yang

Affiliations

  1. Department of Medicine, Developmental and Molecular Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx NY 10461, USA.

PMID: 23662249 PMCID: PMC3646376

Abstract

Natural polyphenols, such as resveratrol, have beneficial functions on major human diseases such as cancer, diabetes, and cardiovascular disease. Besides acting as antioxidants, some of these polyphenols can also target proteins to modulate specific biological pathways. The lysine-specific histone demethylase LSD1 plays important roles in cell growth, differentiation and nutrient metabolism. Here, we studied the effect of natural polyphenols resveratrol, curcumin, quercetin and analogs on LSD1. Using

Keywords: LSD1; curcumin; demethylation; myogenesis; polyphenol; quercetin; resveratrol

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