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Chun TH. Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis. Adipocyte. 2012;1(2):89-95doi: 10.4161/adip.19752.
Chun, T. H. (2012). Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis. Adipocyte, 1(2), 89-95. https://doi.org/10.4161/adip.19752
Chun, Tae-Hwa. "Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis." Adipocyte vol. 1,2 (2012): 89-95. doi: https://doi.org/10.4161/adip.19752
Chun TH. Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis. Adipocyte. 2012 Apr 01;1(2):89-95. doi: 10.4161/adip.19752. PMID: 23700517; PMCID: PMC3609086.
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Adipocyte. 2012 Apr 01;1(2):89-95. doi: 10.4161/adip.19752.

Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis.

Adipocyte

Tae-Hwa Chun

Affiliations

  1. Department of Internal Medicine; Division of Metabolism, Endocrinology & Diabetes; University of Michigan Medical School; Ann Arbor, MI USA.

PMID: 23700517 PMCID: PMC3609086 DOI: 10.4161/adip.19752

Abstract

Adipocytes differentiate and function in environments rich in extracellular matrix (ECM) proteins. The phenotypes of genetically modified mice have aided in recognizing the importance of ECM proteins and their modifiers, e.g., proteinases, in the regulation of obesity and metabolism. Most of the molecular mechanisms through which ECM proteins and modifiers regulate adipogenesis or adipocyte function have not been fully defined. Adipose tissue fibrosis may be a factor that links obesity to diabetes or cardiovascular disease risk in conjunction with tissue inflammation. Defining the molecular mechanisms through which the ECM environment regulates adipogenesis and adipocyte function should provide us with a better understanding of the disease link between obesity and diabetes or cardiovascular diseases.

Keywords: ECM; MMP; fibrosis; inflammation; obesity

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