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Zeng X, Lin J. Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria. Front Microbiol. 2013;4:128doi: 10.3389/fmicb.2013.00128.
Zeng, X., & Lin, J. (2013). Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria. Frontiers in microbiology, 4128. https://doi.org/10.3389/fmicb.2013.00128
Zeng, Ximin, and Lin, Jun. "Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria." Frontiers in microbiology vol. 4 (2013): 128. doi: https://doi.org/10.3389/fmicb.2013.00128
Zeng X, Lin J. Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria. Front Microbiol. 2013 May 22;4:128. doi: 10.3389/fmicb.2013.00128. eCollection 2013. PMID: 23734147; PMCID: PMC3660660.
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Front Microbiol. 2013 May 22;4:128. doi: 10.3389/fmicb.2013.00128. eCollection 2013.

Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria.

Frontiers in microbiology

Ximin Zeng, Jun Lin

Affiliations

  1. Department of Animal Science, The University of Tennessee Knoxville, TN, USA.

PMID: 23734147 PMCID: PMC3660660 DOI: 10.3389/fmicb.2013.00128

Abstract

Production of beta-lactamases, the enzymes that degrade beta-lactam antibiotics, is the most widespread and threatening mechanism of antibiotic resistance. In the past, extensive research has focused on the structure, function, and ecology of beta-lactamases while limited efforts were placed on the regulatory mechanisms of beta-lactamases. Recently, increasing evidence demonstrate a direct link between beta-lactamase induction and cell wall metabolism in Gram-negative bacteria. Specifically, expression of beta-lactamase could be induced by the liberated murein fragments, such as muropeptides. This article summarizes current knowledge on cell wall metabolism, beta-lactam antibiotics, and beta-lactamases. In particular, we comprehensively reviewed recent studies on the beta-lactamase induction by muropeptides via two major molecular mechanisms (the AmpG-AmpR-AmpC pathway and BlrAB-like two-component regulatory system) in Gram-negative bacteria. The signaling pathways for beta-lactamase induction offer a broad array of promising targets for the discovery of new antibacterial drugs used for combination therapies. Therefore, to develop effective mitigation strategies against the widespread beta-lactam resistance, examination of the molecular basis of beta-lactamase induction by cell wall fragment is highly warranted.

Keywords: beta-lactamase; peptidoglycan; regulation

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