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Boskabady MH, Vatanprast A, Parsaee H, et al. Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart. Daru. 2013;21(1):38doi: 10.1186/2008-2231-21-38.
Boskabady, M. H., Vatanprast, A., Parsaee, H., & Boskabady, M. (2013). Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 21(1), 38. https://doi.org/10.1186/2008-2231-21-38
Boskabady, Mohammad Hossein, et al. "Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart." Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences vol. 21,1 (2013): 38. doi: https://doi.org/10.1186/2008-2231-21-38
Boskabady MH, Vatanprast A, Parsaee H, Boskabady M. Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart. Daru. 2013 May 20;21(1):38. doi: 10.1186/2008-2231-21-38. PMID: 23688388; PMCID: PMC3661371.
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Daru. 2013 May 20;21(1):38. doi: 10.1186/2008-2231-21-38.

Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Mohammad Hossein Boskabady, Alaleh Vatanprast, Haydar Parsaee, Morteza Boskabady

Affiliations

  1. Applied Physiology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran. [email protected].

PMID: 23688388 PMCID: PMC3661371 DOI: 10.1186/2008-2231-21-38

Abstract

BACKGROUND: The possible mechanism(s) of inotropic and chronotropic effects of the extract from Rosa damascena (R. damascena) on heart was examined.

METHODS: Inotropic and chronotropic effects of four concentrations of the extract from R. damascena and isoprenaline were examined in isolated guinea-pig hearts perfused through aorta in a Langendorff model. All measurements were performed in three different groups: 1) In the presence and absence of propranolol, 2) In the presence and absence of methacholine and 3) In the presence of diltiazem (n = 12 for each group).

RESULTS: In all groups both isoprenaline and the extract caused an increase in heart rate and contractility (p < 0.05 to p < 0.001). Only in group 1, the final concentration of isoprenaline in the absence of propranolol caused significant greater increase in heart rate compared to the extract (207.6 ± 11.0 compared to 162.6 ± 11.8, p < 0.01). The percent increase in heart contractility due to the final concentration of the extract in the absence (362.4 ± 36.9 compared to 227.7 ± 31.6, p < 0.01) and presence of propranolol (577.1 ± 62.9 compared to 357.5 ± 45.6, p < 0.001) in group 1 and absence (403.7 ± 42.1 compared to 244.8 ± 18.9, p < 0.005) and presence of methcholine (499.88 ± 64.64 compared to 323.90 ± 44.49, p < 0.05) in groups 2 was significantly greater than the increase caused by isoprenaline.

CONCLUSIONS: The results of this study suggest that inotropic and chornotropic effect of R. damascena is possibly due to the stimulatory effect of this plant on beta-adrenoceptors.

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