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Börnigen D, Morgan XC, Franzosa EA, et al. Functional profiling of the gut microbiome in disease-associated inflammation. Genome Med. 2013;5(7):65doi: 10.1186/gm469.
Börnigen, D., Morgan, X. C., Franzosa, E. A., Ren, B., Xavier, R. J., Garrett, W. S., & Huttenhower, C. (2013). Functional profiling of the gut microbiome in disease-associated inflammation. Genome medicine, 5(7), 65. https://doi.org/10.1186/gm469
Börnigen, Daniela, et al. "Functional profiling of the gut microbiome in disease-associated inflammation." Genome medicine vol. 5,7 (2013): 65. doi: https://doi.org/10.1186/gm469
Börnigen D, Morgan XC, Franzosa EA, Ren B, Xavier RJ, Garrett WS, Huttenhower C. Functional profiling of the gut microbiome in disease-associated inflammation. Genome Med. 2013 Jul 31;5(7):65. doi: 10.1186/gm469. eCollection 2013. PMID: 23906180; PMCID: PMC3978847.
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Genome Med. 2013 Jul 31;5(7):65. doi: 10.1186/gm469. eCollection 2013.

Functional profiling of the gut microbiome in disease-associated inflammation.

Genome medicine

Daniela Börnigen, Xochitl C Morgan, Eric A Franzosa, Boyu Ren, Ramnik J Xavier, Wendy S Garrett, Curtis Huttenhower

Affiliations

  1. Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  2. Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
  3. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA ; Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02115, USA.
  4. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA ; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

PMID: 23906180 PMCID: PMC3978847 DOI: 10.1186/gm469

Abstract

The microbial residents of the human gut are a major factor in the development and lifelong maintenance of health. The gut microbiota differs to a large degree from person to person and has an important influence on health and disease due to its interaction with the human immune system. Its overall composition and microbial ecology have been implicated in many autoimmune diseases, and it represents a particularly important area for translational research as a new target for diagnostics and therapeutics in complex inflammatory conditions. Determining the biomolecular mechanisms by which altered microbial communities contribute to human disease will be an important outcome of current functional studies of the human microbiome. In this review, we discuss functional profiling of the human microbiome using metagenomic and metatranscriptomic approaches, focusing on the implications for inflammatory conditions such as inflammatory bowel disease and rheumatoid arthritis. Common themes in gut microbial ecology have emerged among these diverse diseases, but they have not yet been linked to targetable mechanisms such as microbial gene and genome composition, pathway and transcript activity, and metabolism. Combining these microbial activities with host gene, transcript and metabolic information will be necessary to understand how and why these complex interacting systems are altered in disease-associated inflammation.

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