Display options
Cite
Demidova MM, Smith JG, Höijer CJ, et al. Prognostic impact of early ventricular fibrillation in patients with ST-elevation myocardial infarction treated with primary PCI. Eur Heart J Acute Cardiovasc Care. 2012;1(4):302-11doi: 10.1177/2048872612463553.
Demidova, M. M., Smith, J. G., Höijer, C. J., Holmqvist, F., Erlinge, D., & Platonov, P. G. (2012). Prognostic impact of early ventricular fibrillation in patients with ST-elevation myocardial infarction treated with primary PCI. European heart journal. Acute cardiovascular care, 1(4), 302-11. https://doi.org/10.1177/2048872612463553
Demidova, Marina M, et al. "Prognostic impact of early ventricular fibrillation in patients with ST-elevation myocardial infarction treated with primary PCI." European heart journal. Acute cardiovascular care vol. 1,4 (2012): 302-11. doi: https://doi.org/10.1177/2048872612463553
Demidova MM, Smith JG, Höijer CJ, Holmqvist F, Erlinge D, Platonov PG. Prognostic impact of early ventricular fibrillation in patients with ST-elevation myocardial infarction treated with primary PCI. Eur Heart J Acute Cardiovasc Care. 2012 Dec;1(4):302-11. doi: 10.1177/2048872612463553. PMID: 24062921; PMCID: PMC3760561.
Copy Download .nbib Format: NLM
Share it on

Eur Heart J Acute Cardiovasc Care. 2012 Dec;1(4):302-11. doi: 10.1177/2048872612463553.

Prognostic impact of early ventricular fibrillation in patients with ST-elevation myocardial infarction treated with primary PCI.

European heart journal. Acute cardiovascular care

Marina M Demidova, J Gustav Smith, Carl-Johan Höijer, Fredrik Holmqvist, David Erlinge, Pyotr G Platonov

Affiliations

  1. Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg, Russia ; Department of Cardiology, Lund University, Lund, Sweden.

PMID: 24062921 PMCID: PMC3760561 DOI: 10.1177/2048872612463553

Abstract

AIMS: Current guidelines do not advocate implantation of cardioverter-defibrillators (ICD) for survivors of ventricular fibrillation (VF) during the first 48 hours of ST-elevation myocardial infarction (STEMI). However, contemporary studies in a real-life setting with long-term follow-up are lacking. We assessed the prognostic impact of early VF in a non-selected population of STEMI patients treated with primary percutaneous coronary intervention (PCI).

METHODS AND RESULTS: Consecutive STEMI patients admitted to a Swedish tertiary care hospital during 2007-2009 were identified from the Register of Information and Knowledge about Swedish Heart Intensive Care Admissions (n=1718, age 66±12 years, 70% male). Patients with VF were identified from the register, and medical records were reviewed to determine the time point of VF. Patients surviving VF in the first 48 hours after symptom onset were compared with patients without VF for one-year mortality and a combined endpoint of death, resuscitated VF or appropriate ICD therapy. VF within 48 hours occurred in 7% of STEMI patients (n=121). In patients alive at 48 hours (n=1663), VF patients (n=101) had higher in-hospital mortality (12% vs. 2%, p<0.001). However, in VF patients discharged alive (n=89), mortality was low (1%) and combined endpoint rate (3%) did not differ compared with patients without VF (n=1538; 4% and 4% respectively).

CONCLUSION: In a large non-selected population of STEMI patients treated with primary PCI, VF during the first 48 hours after STEMI is associated with increased in-hospital mortality but does not influence the long-term prognosis for those discharged alive.

Keywords: Ventricular fibrillation; myocardial infarction; primary PCI; prognosis

References

  1. J Card Fail. 2005 Mar;11(2):87-90 - PubMed
  2. J Card Fail. 2009 Nov;15(9):775-81 - PubMed
  3. Eur Heart J. 2003 Jan;24(1):28-66 - PubMed
  4. Am J Cardiol. 1998 Aug 1;82(3):265-71 - PubMed
  5. Circulation. 2004 Aug 31;110(9):e82-292 - PubMed
  6. Eur J Clin Pharmacol. 2007 Oct;63(10):959-71 - PubMed
  7. Am J Cardiol. 1985 Sep 1;56(7):384-9 - PubMed
  8. Am J Cardiol. 2010 May 1;105(9):1229-34 - PubMed
  9. JAMA. 2001 Jan 24-31;285(4):430-6 - PubMed
  10. Heart. 2000 Sep;84(3):258-61 - PubMed
  11. Am Heart J. 2010 Dec;160(6):1042-8 - PubMed
  12. Europace. 2006 Sep;8(9):746-837 - PubMed
  13. Circulation. 1998 Dec 8;98(23):2567-73 - PubMed
  14. J Am Coll Cardiol. 2004 May 19;43(10):1765-72 - PubMed
  15. J Am Coll Cardiol. 1988 Mar;11(3):464-70 - PubMed
  16. JAMA. 2010 Mar 24;303(12):1167-72 - PubMed
  17. Eur Heart J. 1997 Jun;18(6):919-24 - PubMed
  18. Am J Cardiol. 1990 Nov 15;66(17):1208-11 - PubMed
  19. Am J Med. 2008 Sep;121(9):797-804 - PubMed
  20. N Engl J Med. 1997 Feb 20;336(8):525-33 - PubMed
  21. Int J Cardiol. 1994 Jul;45(3):191-8 - PubMed
  22. Eur Heart J. 2010 Jan;31(2):177-86 - PubMed
  23. Am J Cardiol. 1989 May 15;63(17):1174-8 - PubMed
  24. JAMA. 2009 May 6;301(17):1779-89 - PubMed

Publication Types