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Zhao T, Mauger T, Li G. Optimization of wavefront-coded infinity-corrected microscope systems with extended depth of field. Biomed Opt Express. 2013;4(8):1464-71doi: 10.1364/BOE.4.001464.
Zhao, T., Mauger, T., & Li, G. (2013). Optimization of wavefront-coded infinity-corrected microscope systems with extended depth of field. Biomedical optics express, 4(8), 1464-71. https://doi.org/10.1364/BOE.4.001464
Zhao, Tingyu, et al. "Optimization of wavefront-coded infinity-corrected microscope systems with extended depth of field." Biomedical optics express vol. 4,8 (2013): 1464-71. doi: https://doi.org/10.1364/BOE.4.001464
Zhao T, Mauger T, Li G. Optimization of wavefront-coded infinity-corrected microscope systems with extended depth of field. Biomed Opt Express. 2013 Jul 31;4(8):1464-71. doi: 10.1364/BOE.4.001464. eCollection 2013. PMID: 24010008; PMCID: PMC3756573.
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Biomed Opt Express. 2013 Jul 31;4(8):1464-71. doi: 10.1364/BOE.4.001464. eCollection 2013.

Optimization of wavefront-coded infinity-corrected microscope systems with extended depth of field.

Biomedical optics express

Tingyu Zhao, Thomas Mauger, Guoqiang Li

Affiliations

  1. Department of Ophthalmology and Visual Science, The Ohio State University, Columbus, OH 43212, USA ; Department of Electrical and Computer Engineering, The Ohio State University, ElectroScience Laboratory, 1330 Kinnear Road., Columbus, OH 43212, USA.

PMID: 24010008 PMCID: PMC3756573 DOI: 10.1364/BOE.4.001464

Abstract

The depth of field of an infinity-corrected microscope system is greatly extended by simply applying a specially designed phase mask between the objective and the tube lens. In comparison with the method of modifying the structure of objective, it is more cost effective and provides improved flexibility for assembling the system. Instead of using an ideal optical system for simulation which was the focus of the previous research, a practical wavefront-coded infinity-corrected microscope system is designed in this paper by considering the various aberrations. Two new optimization methods, based on the commercial optical design software, are proposed to design a wavefront-coded microscope using a non-symmetric phase mask and a symmetric phase mask, respectively. We use polynomial phase mask and rational phase mask as examples of the non-symmetric and symmetric phase masks respectively. Simulation results show that both optimization methods work well for a 32 × infinity-corrected microscope system with 0.6 numerical aperture. The depth of field is extended to about 13 times of the traditional one.

Keywords: (080.2740) Geometric optical design; (110.0180) Microscopy; (110.1085) Adaptive imaging; (110.1758) Computational imaging; (110.7348) Wavefront encoding; (220.4830) Systems design

References

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  2. Appl Opt. 1995 Apr 10;34(11):1859-66 - PubMed
  3. Opt Lett. 2011 Aug 15;36(16):3021-3 - PubMed
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Grant support