Display options
Share it on

J Dermatol Case Rep. 2013 Sep 30;7(3):97-100. doi: 10.3315/jdcr.2013.1146. eCollection 2013.

A Unique Case of Classic Kaposi's sarcoma restricted to the toes.

Journal of dermatological case reports

Anne S Renteria, Vickie A Marshall, Yanyu Sun, Porselvi Chockalingam, Jay S Cooper, Yiwu Huang, Denise Whitby

Affiliations

  1. Mount Sinai Medical Center, New York, NY 10029, USA;

PMID: 24133565 PMCID: PMC3797018 DOI: 10.3315/jdcr.2013.1146

Abstract

BACKGROUND: Kaposi's sarcoma associated-herpesvirus causes all forms of Kaposi's sarcoma, and six major subtypes have been described based on the amino acid sequences of the open reading frame K1.

MAIN OBSERVATION: A 71-year-old man from China, HIV negative, presented with nodules on the dorsal aspect of his toes. Biopsy confirmed the diagnosis of Kaposi's sarcoma and virology studies of his blood and saliva confirmed the presence of Kaposi's sarcoma associated-herpesvirus infection. Viral genotyping was consistent with subtype C3. Intervention has been deferred as our patient has remained clinically asymptomatic and without evident growth of his lesions over a 2-year follow up.

CONCLUSIONS: We herein report the first known case of Kaposi's sarcoma restricted to the toes caused by the viral subtype C3 in an HIV-negative patient from Harbin, China.

Keywords: China; HIV; KSHV; Kaposi's sarcoma; human herpesvirus-8 subtypes; viral phylogeny

References

  1. Arch Pathol Lab Med. 2013 Feb;137(2):289-94 - PubMed
  2. Blood. 1995 Aug 15;86(4):1276-80 - PubMed
  3. J Infect Dis. 2007 Mar 1;195(5):645-59 - PubMed
  4. Mol Biol Evol. 1987 Jul;4(4):406-25 - PubMed
  5. J Clin Virol. 2002 Jan;23(3):119-48 - PubMed
  6. J Am Acad Dermatol. 2013 Feb;68(2):313-31 - PubMed
  7. J Med Virol. 2009 Aug;81(8):1422-31 - PubMed
  8. J Am Acad Dermatol. 2008 Aug;59(2):179-206; quiz 207-8 - PubMed
  9. J Infect. 2007 Jul;55(1):89-90 - PubMed
  10. J Immunol Methods. 2010 Apr 30;356(1-2):39-46 - PubMed
  11. J Virol. 1999 May;73(5):4156-70 - PubMed
  12. J Genet Genomics. 2008 Nov;35(11):657-63 - PubMed
  13. Science. 1994 Dec 16;266(5192):1865-9 - PubMed
  14. N Engl J Med. 2000 Apr 6;342(14):1027-38 - PubMed
  15. Lancet. 1995 Sep 23;346(8978):799-802 - PubMed
  16. J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):460-7 - PubMed
  17. Lancet. 1995 Apr 22;345(8956):1043-4 - PubMed
  18. N Engl J Med. 1995 May 4;332(18):1186-91 - PubMed
  19. J Infect Dis. 2009 May 15;199(10):1449-56 - PubMed
  20. Intervirology. 2006;49(3):133-43 - PubMed
  21. J Infect Dis. 2006 May 1;193(9):1250-7 - PubMed
  22. Cancer Lett. 2011 Jun 28;305(2):150-62 - PubMed
  23. Pathol Int. 2001 Nov;51(11):845-52 - PubMed

Publication Types

Grant support