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Future Oncol. 2013 Oct;9(10):1501-13. doi: 10.2217/fon.13.123.

Endoscopic molecular imaging of cancer.

Future oncology (London, England)

Towhid Ali, Peter L Choyke, Hisataka Kobayashi

Affiliations

  1. Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1088, USA.

PMID: 24106901 PMCID: PMC7537976 DOI: 10.2217/fon.13.123

Abstract

White light endoscopy has proven to be a very powerful tool in oncology. There is still, however, a need for better endoscopic techniques to overcome the current limitations of white light optics. New technologies that allow higher sensitivity, improved microanatomy and molecular characterization have been available for in vitro microscopy and are now being translated into in vivo endoscopy. Endoscopic molecular imaging is still in its infancy but holds the promise for enhancing sensitivity for early lesions, thus allowing earlier diagnosis and enabling early image-guided endoscopic intervention. A key feature of endoscopic molecular imaging is its increased sensitivity and specificity, which will be illustrated in this article, as well as describing perspectives on its future use in oncologic surgery.

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