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Pesonen M, Hansson T, Förlin L, et al. Regional distribution of microsomal xenobiotic and steroid metabolism in kidney microsomes from rainbow trout. Fish Physiol Biochem. 1990;8(2):141-5doi: 10.1007/BF00004441.
Pesonen, M., Hansson, T., Förlin, L., & Andersson, T. (1990). Regional distribution of microsomal xenobiotic and steroid metabolism in kidney microsomes from rainbow trout. Fish physiology and biochemistry, 8(2), 141-5. https://doi.org/10.1007/BF00004441
Pesonen, M, et al. "Regional distribution of microsomal xenobiotic and steroid metabolism in kidney microsomes from rainbow trout." Fish physiology and biochemistry vol. 8,2 (1990): 141-5. doi: https://doi.org/10.1007/BF00004441
Pesonen M, Hansson T, Förlin L, Andersson T. Regional distribution of microsomal xenobiotic and steroid metabolism in kidney microsomes from rainbow trout. Fish Physiol Biochem. 1990 Mar;8(2):141-5. doi: 10.1007/BF00004441. PMID: 24221947.
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Fish Physiol Biochem. 1990 Mar;8(2):141-5. doi: 10.1007/BF00004441.

Regional distribution of microsomal xenobiotic and steroid metabolism in kidney microsomes from rainbow trout.

Fish physiology and biochemistry

M Pesonen, T Hansson, L Förlin, T Andersson

Affiliations

  1. Department of Zoophysiology, University of Göteborg, Box 25059, S 400 31, Göteborg, Sweden.

PMID: 24221947 DOI: 10.1007/BF00004441

Abstract

The regional distribution of microsomal cytochrome P-450-mediated reactions with exogenous and endogenous substrates in the kidney of rainbow trout was studied. The cytochrome P-450-dependent 7-ethoxyresorufin- and 7-ethoxycoumarin-0-deethylase activities were significantly higher (3-4 and 10-14 fold, respectively) in the trunk kidney than in the head kidney, whereas ethylmorphine-N-demethylase activity was evenly distributed along the kidney. The microsomal cytochrome P-450-dependent steroid hydroxylases and steroid reducing enzymes when using androstenedione as substrate also exhibited a regional distribution in trout kidney. The 6β- and 16-hydroxylase activities as well as the 5α-reductase and 17 hydroxysteroid oxidoreductase activities were higher in the anterior part of the trunk kidney than in the head kidney and posterior trunk kidney.

References

  1. Gen Comp Endocrinol. 1981 Jun;44(2):181-8 - PubMed
  2. Biochem Pharmacol. 1979 Dec 1;28(23):3431-9 - PubMed
  3. Gen Comp Endocrinol. 1969 Feb;12(1):99-109 - PubMed
  4. Pharmacol Rev. 1967 Sep;19(3):317-66 - PubMed
  5. Toxicol Appl Pharmacol. 1984 Jul;74(3):430-49 - PubMed
  6. Biochem Pharmacol. 1987 Mar 15;36(6):823-9 - PubMed
  7. Arch Biochem Biophys. 1984 Jun;231(2):503-10 - PubMed
  8. Toxicol Appl Pharmacol. 1979 Jul;49(3):437-50 - PubMed
  9. Toxicol Appl Pharmacol. 1987 Oct;91(1):75-84 - PubMed
  10. Biochem Pharmacol. 1984 Dec 1;33(23):3743-53 - PubMed
  11. Biochim Biophys Acta. 1982 Aug 27;717(3):398-404 - PubMed
  12. Gen Comp Endocrinol. 1979 Feb;37(2):240-5 - PubMed
  13. Environ Health Perspect. 1987 Apr;71:87-95 - PubMed
  14. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
  15. Drug Metab Dispos. 1974 Nov-Dec;2(6):545-555 - PubMed
  16. Ann N Y Acad Sci. 1979 May 31;320:193-203 - PubMed
  17. Environ Health Perspect. 1987 Apr;71:105-19 - PubMed
  18. Biochem Pharmacol. 1980 Feb 15;29(4):553-8 - PubMed
  19. Toxicol Appl Pharmacol. 1980 Jul;54(3):420-30 - PubMed
  20. Comp Biochem Physiol C Comp Pharmacol. 1981;69(2):259-63 - PubMed
  21. Biochem Pharmacol. 1986 Jun 15;35(12):2017-23 - PubMed
  22. J Endocrinol. 1982 Nov;95(2):245-52 - PubMed

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