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Talia JM, Tonn CE, Debattista NB, et al. Antibacterial Efficacy of Dihydroxylated Chalcones in Binary and Ternary Combinations with Nalidixic Acid and Nalidix Acid-Rutin Against Escherichia coli ATCC 25 922. Indian J Microbiol. 2012;52(4):638-41doi: 10.1007/s12088-012-0302-y.
Talia, J. M., Tonn, C. E., Debattista, N. B., & Pappano, N. B. (2012). Antibacterial Efficacy of Dihydroxylated Chalcones in Binary and Ternary Combinations with Nalidixic Acid and Nalidix Acid-Rutin Against Escherichia coli ATCC 25 922. Indian journal of microbiology, 52(4), 638-41. https://doi.org/10.1007/s12088-012-0302-y
Talia, Juan Manuel, et al. "Antibacterial Efficacy of Dihydroxylated Chalcones in Binary and Ternary Combinations with Nalidixic Acid and Nalidix Acid-Rutin Against Escherichia coli ATCC 25 922." Indian journal of microbiology vol. 52,4 (2012): 638-41. doi: https://doi.org/10.1007/s12088-012-0302-y
Talia JM, Tonn CE, Debattista NB, Pappano NB. Antibacterial Efficacy of Dihydroxylated Chalcones in Binary and Ternary Combinations with Nalidixic Acid and Nalidix Acid-Rutin Against Escherichia coli ATCC 25 922. Indian J Microbiol. 2012 Dec;52(4):638-41. doi: 10.1007/s12088-012-0302-y. Epub 2012 Aug 31. PMID: 24293723; PMCID: PMC3516650.
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Indian J Microbiol. 2012 Dec;52(4):638-41. doi: 10.1007/s12088-012-0302-y. Epub 2012 Aug 31.

Antibacterial Efficacy of Dihydroxylated Chalcones in Binary and Ternary Combinations with Nalidixic Acid and Nalidix Acid-Rutin Against Escherichia coli ATCC 25 922.

Indian journal of microbiology

Juan Manuel Talia, Carlos Eugenio Tonn, Nora Beatriz Debattista, Nora Beatriz Pappano

Affiliations

  1. Area of Physical Chemistry, Department of Chemistry, San Luis National University, 5700 San Luis, Argentina.

PMID: 24293723 PMCID: PMC3516650 DOI: 10.1007/s12088-012-0302-y

Abstract

In order to determine the existence of synergism, the bacteriostatic action of flavonoids against Escherichia coli ATCC 25 922 between dihydroxylated chalcones and a clinically interesting conventional antibiotic, binary combinations of 2',3-dihydroxychalcone, 2',4-dihydroxychalcone and 2',4'-dihydroxychalcone with nalidixic acid and its ternary combinations with rutin (inactive flavonoid) were assayed against this Gram negative bacterium. Using a kinetic-turbidimetric method, growth kinetics were monitored in broths containing variable amounts of dihydroxychalcone alone, combinations of dihydroxychalcone variable concentration-nalidixic acid constant concentration and dihydroxychalcone variable concentration-nalidixic acid constant concentration-rutin constant concentration, respectively. The minimum inhibitory concentrations of dihydroxychalcones alone and its binary and ternary combinations were evaluated. All chalcones, and their binary and ternary combinations showed antibacterial activity, being rutin an excellent synergizing for the dihydroxychalcone-nalidixic acid binary combination against E. coli ATCC 25 922. Thus, this synergistic effect is an important way that could lead to the development of new combination antibiotics against infections caused by E. coli.

Keywords: Dihydroxylated chalcones; Escherichia coli; Nalidixic acid; Synergism

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