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Lewin E, Bleck V. Release of(14)C-adenine derivatives from cerebral cortical slices: Effect of phenytoin and phenobarbital. Neurochem Res. 1976;1(4):429-35doi: 10.1007/BF00966234.
Lewin, E., & Bleck, V. (1976). Release of(14)C-adenine derivatives from cerebral cortical slices: Effect of phenytoin and phenobarbital. Neurochemical research, 1(4), 429-35. https://doi.org/10.1007/BF00966234
Lewin, E, and Bleck, V. "Release of(14)C-adenine derivatives from cerebral cortical slices: Effect of phenytoin and phenobarbital." Neurochemical research vol. 1,4 (1976): 429-35. doi: https://doi.org/10.1007/BF00966234
Lewin E, Bleck V. Release of(14)C-adenine derivatives from cerebral cortical slices: Effect of phenytoin and phenobarbital. Neurochem Res. 1976 Aug;1(4):429-35. doi: 10.1007/BF00966234. PMID: 24271574.
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Neurochem Res. 1976 Aug;1(4):429-35. doi: 10.1007/BF00966234.

Release of(14)C-adenine derivatives from cerebral cortical slices: Effect of phenytoin and phenobarbital.

Neurochemical research

E Lewin, V Bleck

Affiliations

  1. Neurology Service, Veterans Administration Hospital, and Department of Neurology, University of Colorado Medical Center, Denver, Colorado.

PMID: 24271574 DOI: 10.1007/BF00966234

Abstract

Both ouabain, 0.1 mM, and veratridine, 0.05 mM, increased the release of(14)C-labeled compounds from rat cortical slices prelabeled with(14)C-adenine and incubated in vitro. The increment in radioactivity released by both depolarizing agents was almost entirely a result of increases in adenosine, inosine, and hypoxanthine. However, the distribution of these three compounds in the ouabain-induced efflux (adenosine, 12%; inosine, 51%; hypoxanthine, 36%) contrasted with that evoked by veratridine (adenosine, 42%; inosine, 15%; hypoxanthine, 38%). Phenytoin significantly reduced the efflux of(14)C-labeled compounds produced by both ouabain and veratridine, but phenobarbital had no effect. The intracortical injection of adenosine, inosine, and hypoxanthine has been shown to induce epileptiform discharges in rats, and it is suggested that the inhibitory effect of phenytoin on the release of adenine derivatives may play a role in its antiepileptic action.

References

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