Display options
Cite
Hidaka T, Shiwa T, Fujii Y, et al. Impact of aldosterone-producing adenoma on cardiac structures in echocardiography. J Echocardiogr. 2013;11:123-9doi: 10.1007/s12574-013-0168-y.
Hidaka, T., Shiwa, T., Fujii, Y., Nishioka, K., Utsunomiya, H., Ishibashi, K., Mitsuba, N., Dohi, Y., Oda, N., Noma, K., Kurisu, S., Nakano, Y., Yamamoto, H., Iishida, T., Higashi, Y., & Kihara, Y. (2013). Impact of aldosterone-producing adenoma on cardiac structures in echocardiography. Journal of echocardiography, 11123-9. https://doi.org/10.1007/s12574-013-0168-y
Hidaka, Takayuki, et al. "Impact of aldosterone-producing adenoma on cardiac structures in echocardiography." Journal of echocardiography vol. 11 (2013): 123-9. doi: https://doi.org/10.1007/s12574-013-0168-y
Hidaka T, Shiwa T, Fujii Y, Nishioka K, Utsunomiya H, Ishibashi K, Mitsuba N, Dohi Y, Oda N, Noma K, Kurisu S, Nakano Y, Yamamoto H, Iishida T, Higashi Y, Kihara Y. Impact of aldosterone-producing adenoma on cardiac structures in echocardiography. J Echocardiogr. 2013;11:123-9. doi: 10.1007/s12574-013-0168-y. Epub 2013 Feb 05. PMID: 24319340; PMCID: PMC3851697.
Copy Download .nbib Format: NLM
Share it on

J Echocardiogr. 2013;11:123-9. doi: 10.1007/s12574-013-0168-y. Epub 2013 Feb 05.

Impact of aldosterone-producing adenoma on cardiac structures in echocardiography.

Journal of echocardiography

Takayuki Hidaka, Tsuguka Shiwa, Yuichi Fujii, Kenji Nishioka, Hiroto Utsunomiya, Ken Ishibashi, Naoya Mitsuba, Yoshihiro Dohi, Noboru Oda, Kensuke Noma, Satoru Kurisu, Yukiko Nakano, Hideya Yamamoto, Takafumi Iishida, Yukihito Higashi, Yasuki Kihara

Affiliations

  1. Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences and Health, Kasumi 1-2-3, Minami-ku, Hiroshima Japan.

PMID: 24319340 PMCID: PMC3851697 DOI: 10.1007/s12574-013-0168-y

Abstract

BACKGROUND: Primary aldosteronism (PA) is a most common cause of secondary hypertension. In PA, left ventricular hypertrophy (LVH) is more progressive than in any other cause of hypertension. Aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) are major subtypes of PA. However there is little information concerned with differences of cardiac structures between these two subtypes.

METHODS: We reviewed echocardiographic findings in 46 patients with PA. All patients had a positive screen test and subtypes of PA were confirmed by adrenal vein sampling. Subjects consisted of 20 patients with APA (APA group, 52.4 ± 10.8 years) and 26 patients with IHA (IHA group, 56.2 ± 9.5 years). We investigated differences of cardiac structures and functions in the left atrium and ventricle between the APA group and IHA group.

RESULTS: In terms of clinical characteristics, the height and duration of hypertension were greater and serum potassium concentration and BMI were lower in the APA group than in the IHA group. Plasma aldosterone concentration (PAC) and PAC to plasma renin activity ratio were higher in the APA group than in the IHA group. In echocardiographic assessment, the left atrial volume, left ventricular end-diastolic and end-systolic diameters, left ventricular mass (LVM), and prevalence of LVH were greater in the APA group than in the IHA group. Multiple linear regression analysis revealed that the diagnosis of APA independently correlated with left atrial volume, left ventricular end-diastolic diameter, and LVM.

CONCLUSIONS: We demonstrated that differences of cardiac structures between the APA group and IHA group existed. In APA, left atrial enlargement and LVH were more prominent than in IHA.

Keywords: Aldosterone; Echocardiography; Hypertension; Hypertrophy

References

  1. Hypertension. 1987 Feb;9(2 Pt 2):II19-26 - PubMed
  2. Am J Hypertens. 1993 Nov;6(11 Pt 1):907-13 - PubMed
  3. Am J Cardiol. 1993 Jan 21;71(3):12A-16A - PubMed
  4. Hypertension. 1997 Mar;29(3):723-7 - PubMed
  5. Hypertension. 2004 May;43(5):957-62 - PubMed
  6. J Hypertens. 2008 Apr;26(4):613-21 - PubMed
  7. Hypertension. 1996 May;27(5):1039-45 - PubMed
  8. Circulation. 1991 Jun;83(6):1849-65 - PubMed
  9. Am Heart J. 1998 Jan;135(1):58-66 - PubMed
  10. Hypertens Res. 1997 Jun;20(2):85-90 - PubMed
  11. Heart. 1997 Jan;77(1):24-31 - PubMed
  12. Am J Cardiol. 1986 Feb 15;57(6):450-8 - PubMed
  13. J Clin Invest. 1994 Jun;93(6):2578-83 - PubMed
  14. Circ Res. 1990 Dec;67(6):1355-64 - PubMed
  15. J Cardiovasc Pharmacol. 1992;20 Suppl 1:S48-54 - PubMed
  16. J Am Soc Echocardiogr. 2005 Dec;18(12):1440-63 - PubMed
  17. J Am Coll Cardiol. 1991 Oct;18(4):1105-11 - PubMed
  18. Hypertension. 2002 Jul;40(1):23-7 - PubMed
  19. J Am Soc Echocardiogr. 2009 Feb;22(2):107-33 - PubMed
  20. Endocr J. 2011;58(9):711-21 - PubMed
  21. N Engl J Med. 1973 Dec 20;289(25):1330-5 - PubMed
  22. Am J Cardiol. 1988 Dec 1;62(17):1224-7 - PubMed
  23. Am J Hypertens. 1996 Jun;9(6):523-8 - PubMed
  24. J Card Fail. 2004 Dec;10(6):511-8 - PubMed

Publication Types