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Muller B, van Egmond D, de Groot EJ, et al. Characterisation of interleukin-10 expression on different vascular structures in allergic nasal mucosa. Clin Transl Allergy. 2014;4(1):2doi: 10.1186/2045-7022-4-2.
Muller, B., van Egmond, D., de Groot, E. J., Fokkens, W. J., & van Drunen, C. M. (2014). Characterisation of interleukin-10 expression on different vascular structures in allergic nasal mucosa. Clinical and translational allergy, 4(1), 2. https://doi.org/10.1186/2045-7022-4-2
Muller, Barbara, et al. "Characterisation of interleukin-10 expression on different vascular structures in allergic nasal mucosa." Clinical and translational allergy vol. 4,1 (2014): 2. doi: https://doi.org/10.1186/2045-7022-4-2
Muller B, van Egmond D, de Groot EJ, Fokkens WJ, van Drunen CM. Characterisation of interleukin-10 expression on different vascular structures in allergic nasal mucosa. Clin Transl Allergy. 2014 Jan 10;4(1):2. doi: 10.1186/2045-7022-4-2. PMID: 24405811; PMCID: PMC3913321.
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Clin Transl Allergy. 2014 Jan 10;4(1):2. doi: 10.1186/2045-7022-4-2.

Characterisation of interleukin-10 expression on different vascular structures in allergic nasal mucosa.

Clinical and translational allergy

Barbara Muller, Danielle van Egmond, Esther Jj de Groot, Wytske J Fokkens, Cornelis M van Drunen

Affiliations

  1. Department of Otorhinolaryngology, AMC, Room L3-104-2, Meibergdreef 9, Amsterdam 1100 DD, The Netherlands. [email protected].

PMID: 24405811 PMCID: PMC3913321 DOI: 10.1186/2045-7022-4-2

Abstract

BACKGROUND: Interleukin-10 (IL-10) is a negative regulator of immune responses and was previously shown to be expressed by human nasal endothelial cells, while the adhesion molecule MECA-79 plays a role in trans-endothelial migration of immune competent cells. In this study we investigate the relationship between endothelial IL-10 and MECA-79 expression to address the question whether immune competent cells could be affected at the mucosal entry site.

METHODS: Nasal turbinate biopsies were taken from house dust mite allergic patients, before and after nasal allergen provocation. Subsequent slides of biopsies were stained for IL10, MECA-79, CD34, and IL10-Receptor. Capillaries, arteries/veins, and sinusoids were evaluated separately.

RESULTS: 90% of sinusoids are IL-10 positive and all sinusoids are negative for MECA-79, while 4.8% of capillaries are positive for IL-10, and 2.2% are positive for MECA-79. Although about 47% of arteries/veins are positive for IL-10 and 57.1% are positive for MECA-79, only about 20% are positive for both markers. Furthermore, we showed that the myo-fibroblasts surrounding all sinusoids stain positive for IL10R.

CONCLUSIONS: IL10 expression on vascular structures is not related to MECA expression for sinusoids and capillaries and only partly related on arteries/veins, however sinusoidal endothelial IL10 expression is always seen in combination with IL-10R expression of sinusoidal myo-fibroblasts.

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