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Bidulescu A, Liu J, Chen Z, et al. Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in african americans: the jackson heart study. Front Public Health. 2013;1:16doi: 10.3389/fpubh.2013.00016.
Bidulescu, A., Liu, J., Chen, Z., Hickson, D. A., Musani, S. K., Samdarshi, T. E., Fox, E. R., Taylor, H. A., & Gibbons, G. H. (2013). Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in african americans: the jackson heart study. Frontiers in public health, 116. https://doi.org/10.3389/fpubh.2013.00016
Bidulescu, Aurelian, et al. "Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in african americans: the jackson heart study." Frontiers in public health vol. 1 (2013): 16. doi: https://doi.org/10.3389/fpubh.2013.00016
Bidulescu A, Liu J, Chen Z, Hickson DA, Musani SK, Samdarshi TE, Fox ER, Taylor HA, Gibbons GH. Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in african americans: the jackson heart study. Front Public Health. 2013 May 24;1:16. doi: 10.3389/fpubh.2013.00016. eCollection 2013. PMID: 24350185; PMCID: PMC3854845.
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Front Public Health. 2013 May 24;1:16. doi: 10.3389/fpubh.2013.00016. eCollection 2013.

Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in african americans: the jackson heart study.

Frontiers in public health

Aurelian Bidulescu, Jiankang Liu, Zhimin Chen, Demarc A Hickson, Solomon K Musani, Tandaw E Samdarshi, Ervin R Fox, Herman A Taylor, Gary H Gibbons

Affiliations

  1. Department of Community Health and Preventive Medicine, Morehouse School of Medicine Atlanta, GA, USA.
  2. Department of Medicine, University of Mississippi Medical Center Jackson, MS, USA.
  3. Rural Health Research Center, University of South Carolina Columbia, SC, USA.
  4. Department of Medicine, University of Mississippi Medical Center Jackson, MS, USA ; School of Health Sciences, Jackson State University Jackson, MS, USA.
  5. National Heart Lung and Blood Institute, National Institutes of Health Bethesda, MD, USA.

PMID: 24350185 PMCID: PMC3854845 DOI: 10.3389/fpubh.2013.00016

Abstract

BACKGROUND: Because the predictive significance of previously reported racial differences in leptin and adiponectin levels remains unclear, we assessed the prospective association of these adipokines with the risk of cardiovascular disease (CVD) events in African Americans, a population with a high prevalence of cardiometabolic risk factors.

METHODS: Serum specimens from 4,571 Jackson Heart Study participants without prevalent CVD at baseline examination (2000-2004) were analyzed for adiponectin and leptin levels. Cox proportional hazard regression models were used to estimate the associations of the two adipokines with incident coronary heart disease (CHD) and incident ischemic stroke.

RESULTS: During 6.2 years average of follow-up, 98 incident CHD and 87 incident ischemic stroke events were documented. Among study participants (64% women; mean age 54 ± 13 years), the mean (standard deviation, SD) was 6.04 (4.32) μg/mL in women and 4.03 (3.14) μg/mL in men for adiponectin and 37.35 (23.90) ng/mL in women and 11.03 (10.05) ng/mL in men for leptin. After multivariable adjustment that included age, body mass index, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, insulin resistance by homeostasis model assessment for insulin resistance, systolic blood pressure, hypertension medication, smoking, and physical activity, adiponectin was directly associated in women with incident stroke, HR = 1.41 (1.04-1.91) per one SD increase (p = 0.03), but not in men (p = 0.42). It was not associated with incident CHD in women or men. Leptin was not associated with incident CHD or incident stroke.

CONCLUSION: In the largest community-based African American cohort, adiponectin was associated among women with a higher risk of incident stroke. Whether adiponectin harbors harmful properties, or it is produced in response to vascular inflammation to counter the atherosclerotic process, or the putative "adiponectin resistance" phenomenon acts, should be further assessed.

Keywords: African Americans; adiponectin; cardiovascular events; cohort study; leptin; minorities; stroke

References

  1. Atherosclerosis. 2007 Nov;195(1):122-8 - PubMed
  2. Stroke. 1999 Feb;30(2):328-37 - PubMed
  3. Stroke. 2008 Feb;39(2):323-8 - PubMed
  4. Atherosclerosis. 2010 Mar;209(1):220-5 - PubMed
  5. Horm Metab Res. 2007 Jan;39(1):1-2 - PubMed
  6. J Clin Endocrinol Metab. 2005 Oct;90(10):5677-83 - PubMed
  7. Circ J. 2009 Apr;73(4):608-14 - PubMed
  8. Am J Epidemiol. 2007 Jan 15;165(2):164-74 - PubMed
  9. JAMA. 2004 Apr 14;291(14):1730-7 - PubMed
  10. Circulation. 2012 Dec 18;126(25):2951-61 - PubMed
  11. Endocr J. 2010;57(9):793-802 - PubMed
  12. Nature. 2006 Dec 14;444(7121):875-80 - PubMed
  13. Diabetes Care. 1999 Jan;22(1):65-70 - PubMed
  14. Ethn Dis. 2005 Autumn;15(4 Suppl 6):S6-56-61 - PubMed
  15. Clin Chem. 2006 May;52(5):797-9 - PubMed
  16. Atherosclerosis. 2011 Nov;219(1):322-9 - PubMed
  17. Kidney Int. 2009 Sep;76(5):567-75 - PubMed
  18. Clin Endocrinol (Oxf). 2010 Jan;72(1):32-7 - PubMed
  19. J Clin Invest. 2006 Jul;116(7):1784-92 - PubMed
  20. Diabetes Metab. 2010 Apr;36(2):137-43 - PubMed
  21. BMC Cardiovasc Disord. 2013 Feb 22;13:9 - PubMed
  22. Curr Hypertens Rep. 2008 Apr;10(2):131-7 - PubMed
  23. Circ Heart Fail. 2011 Nov;4(6):747-53 - PubMed
  24. Nat Med. 2004 May;10(5):524-9 - PubMed
  25. Atherosclerosis. 2007 Apr;191(2):418-26 - PubMed
  26. Atherosclerosis. 2006 Nov;189(1):47-60 - PubMed
  27. J Intern Med. 2004 Aug;256(2):128-36 - PubMed
  28. Cardiovasc Res. 2007 Apr 1;74(1):11-8 - PubMed
  29. Circulation. 2001 Dec 18;104(25):3052-6 - PubMed
  30. J Clin Endocrinol Metab. 2013 Jan;98(1):255-63 - PubMed
  31. J Clin Endocrinol Metab. 2008 Sep;93(9):3357-64 - PubMed
  32. Eur Heart J. 2006 Oct;27(19):2266-8 - PubMed
  33. Ethn Dis. 2003 Fall;13(4):438-55 - PubMed
  34. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):e15-6 - PubMed
  35. J Clin Endocrinol Metab. 2007 Feb;92(2):571-6 - PubMed
  36. Am J Cardiol. 2007 Jul 15;100(2):234-9 - PubMed
  37. Ann Med. 2007;39(7):482-94 - PubMed
  38. Int J Obes (Lond). 2007 May;31(5):770-6 - PubMed
  39. Stroke. 2010 Jul;41(7):1376-81 - PubMed
  40. J Biol Chem. 2002 Aug 16;277(33):29359-62 - PubMed
  41. Cerebrovasc Dis. 2003;15(1-2):63-9 - PubMed
  42. Diabetes. 2005 Feb;54(2):534-9 - PubMed
  43. Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1655-63 - PubMed
  44. Circulation. 2005 Feb 15;111(6):747-53 - PubMed
  45. Ethn Dis. 2005 Autumn;15(4 Suppl 6):S6-1-3 - PubMed
  46. Stroke. 2011 Jul;42(7):1813-20 - PubMed
  47. J Am Coll Cardiol. 2006 Oct 3;48(7):1369-77 - PubMed
  48. J Clin Endocrinol Metab. 2006 Dec;91(12):5044-50 - PubMed
  49. J Clin Endocrinol Metab. 2008 May;93(5):1846-9 - PubMed
  50. Ethn Dis. 2005 Autumn;15(4 Suppl 6):S6-62-70 - PubMed
  51. J Am Coll Cardiol. 2009 Jan 13;53(2):167-75 - PubMed
  52. Circulation. 2006 Aug 15;114(7):623-9 - PubMed
  53. Am J Med Sci. 2004 Sep;328(3):131-44 - PubMed

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