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Ruzevick J, Nicholas S, Redmond K, et al. A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain. Case Rep Oncol Med. 2013;2013:946392doi: 10.1155/2013/946392.
Ruzevick, J., Nicholas, S., Redmond, K., Kleinberg, L., Lipson, E. J., & Lim, M. (2013). A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain. Case reports in oncological medicine, 2013946392. https://doi.org/10.1155/2013/946392
Ruzevick, Jacob, et al. "A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain." Case reports in oncological medicine vol. 2013 (2013): 946392. doi: https://doi.org/10.1155/2013/946392
Ruzevick J, Nicholas S, Redmond K, Kleinberg L, Lipson EJ, Lim M. A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain. Case Rep Oncol Med. 2013;2013:946392. doi: 10.1155/2013/946392. Epub 2013 Dec 08. PMID: 24383025; PMCID: PMC3870634.
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Case Rep Oncol Med. 2013;2013:946392. doi: 10.1155/2013/946392. Epub 2013 Dec 08.

A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain.

Case reports in oncological medicine

Jacob Ruzevick, Sarah Nicholas, Kristin Redmond, Lawrence Kleinberg, Evan J Lipson, Michael Lim

Affiliations

  1. Departments of Neurosurgery, The Johns Hopkins University School of Medicine, Phipps 123 600 N. Wolfe Street, Baltimore, MD 21287, USA.
  2. University of Maryland School of Medicine, Baltimore, MD 21210, USA.
  3. Department of Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  4. Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  5. Departments of Neurosurgery, The Johns Hopkins University School of Medicine, Phipps 123 600 N. Wolfe Street, Baltimore, MD 21287, USA ; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

PMID: 24383025 PMCID: PMC3870634 DOI: 10.1155/2013/946392

Abstract

Cancers, such as melanoma, that are associated with immune deficiencies are a major cause of morbidity and mortality in HIV-infected patients. Once patients develop melanoma metastases to the brain, treatment is often limited to palliative surgery and/or radiation. Ipilimumab, a CTLA-4 antagonist, has been shown to improve the median survival of patients with metastatic melanoma. However, available data regarding the safety and efficacy of ipilimumab in HIV-infected patients who develop intracranial melanoma metastases is limited. Here we report our experience administering ipilimumab to a patient with HIV-AIDS who developed multiple intracranial melanoma metastases. Following treatment, our patient showed improvement in systemic tumor control without any apparent interference with antiretroviral treatment.

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