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Eskazan AE, Salihoglu A, Gulturk E, et al. Successful management of chronic refractory immune thrombocytopenia with laparoscopic splenectomy in a patient with acute promyelocytic leukemia. Indian J Hematol Blood Transfus. 2012;29(3):173-7doi: 10.1007/s12288-012-0173-8.
Eskazan, A. E., Salihoglu, A., Gulturk, E., Aydin, S. O., Tuzuner, N., & Aydin, Y. (2013). Successful management of chronic refractory immune thrombocytopenia with laparoscopic splenectomy in a patient with acute promyelocytic leukemia. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 29(3), 173-7. https://doi.org/10.1007/s12288-012-0173-8
Eskazan, Ahmet Emre, et al. "Successful management of chronic refractory immune thrombocytopenia with laparoscopic splenectomy in a patient with acute promyelocytic leukemia." Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion vol. 29,3 (2013): 173-7. doi: https://doi.org/10.1007/s12288-012-0173-8
Eskazan AE, Salihoglu A, Gulturk E, Aydin SO, Tuzuner N, Aydin Y. Successful management of chronic refractory immune thrombocytopenia with laparoscopic splenectomy in a patient with acute promyelocytic leukemia. Indian J Hematol Blood Transfus. 2013 Sep;29(3):173-7. doi: 10.1007/s12288-012-0173-8. Epub 2012 Jul 17. PMID: 24426368; PMCID: PMC3710553.
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Indian J Hematol Blood Transfus. 2013 Sep;29(3):173-7. doi: 10.1007/s12288-012-0173-8. Epub 2012 Jul 17.

Successful management of chronic refractory immune thrombocytopenia with laparoscopic splenectomy in a patient with acute promyelocytic leukemia.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Ahmet Emre Eskazan, Ayse Salihoglu, Emine Gulturk, Seniz Ongoren Aydin, Nukhet Tuzuner, Yildiz Aydin

Affiliations

  1. Department of Hematology, Diyarbakir Training and Research Hospital, Diyarbakir, Turkey.
  2. Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  3. Department of Pathology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

PMID: 24426368 PMCID: PMC3710553 DOI: 10.1007/s12288-012-0173-8

Abstract

Acute promyelocytic leukemia (APL) is a particular type of acute myeloid leukemia with characteristic biological and clinical features, the frequent association at diagnosis of a severe hemorrhagic diathesis. Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by low platelet counts and an increased risk of bleeding. Here we present a patient with the diagnosis of APL who achieved and maintained a remission with an induction consisting of idarubicin and ATRA, and then developed corticosteroid refractory ITP which is successfully treated with laparoscopic splenectomy.

Keywords: APL; Acute promyelocytic leukemia; ITP; Immune thrombocytopenia; Splenectomy

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