Display options
Cite
Boardman LA, Litzelman K, Seo S, et al. The association of telomere length with colorectal cancer differs by the age of cancer onset. Clin Transl Gastroenterol. 2014;5:e52doi: 10.1038/ctg.2014.3.
Boardman, L. A., Litzelman, K., Seo, S., Johnson, R. A., Vanderboom, R. J., Kimmel, G. W., Cunningham, J. M., Gangnon, R. E., Engelman, C. D., Riegert-Johnson, D. L., Potter, J., Haile, R., Buchanan, D., Jenkins, M. A., Rider, D. N., Thibodeau, S. N., Petersen, G. M., & Skinner, H. G. (2014). The association of telomere length with colorectal cancer differs by the age of cancer onset. Clinical and translational gastroenterology, 5e52. https://doi.org/10.1038/ctg.2014.3
Boardman, Lisa A, et al. "The association of telomere length with colorectal cancer differs by the age of cancer onset." Clinical and translational gastroenterology vol. 5 (2014): e52. doi: https://doi.org/10.1038/ctg.2014.3
Boardman LA, Litzelman K, Seo S, Johnson RA, Vanderboom RJ, Kimmel GW, Cunningham JM, Gangnon RE, Engelman CD, Riegert-Johnson DL, Potter J, Haile R, Buchanan D, Jenkins MA, Rider DN, Thibodeau SN, Petersen GM, Skinner HG. The association of telomere length with colorectal cancer differs by the age of cancer onset. Clin Transl Gastroenterol. 2014 Mar 06;5:e52. doi: 10.1038/ctg.2014.3. PMID: 24598784; PMCID: PMC3972691.
Copy Download .nbib Format: NLM
Share it on

Clin Transl Gastroenterol. 2014 Mar 06;5:e52. doi: 10.1038/ctg.2014.3.

The association of telomere length with colorectal cancer differs by the age of cancer onset.

Clinical and translational gastroenterology

Lisa A Boardman, Kristin Litzelman, Songwon Seo, Ruth A Johnson, Russell J Vanderboom, Grace W Kimmel, Julie M Cunningham, Ronald E Gangnon, Corinne D Engelman, Douglas L Riegert-Johnson, John Potter, Robert Haile, Daniel Buchanan, Mark A Jenkins, David N Rider, Stephen N Thibodeau, Gloria M Petersen, Halcyon G Skinner

Affiliations

  1. Department of Gastroenterology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  2. Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
  3. National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
  4. Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  5. Mayo Clinic Cancer Center, Rochester, Minnesota, USA.
  6. University of Michigan, Ann Arbor, Michigan, USA.
  7. Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
  8. Public Health Sciences Division, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  9. Department of Oncology, Stanford School of Medicine, The Stanford Cancer Institute, Stanford, California, USA.
  10. Queensland Institute of Medical Research, Clive Berghofer Cancer Research Centre, Brisbane, Queensland, Australia.
  11. Melbourne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia.
  12. Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

PMID: 24598784 PMCID: PMC3972691 DOI: 10.1038/ctg.2014.3

Abstract

OBJECTIVES: Telomeres are nucleoprotein structures that cap the end of chromosomes and shorten with sequential cell divisions in normal aging. Short telomeres are also implicated in the incidence of many cancers, but the evidence is not conclusive for colorectal cancer (CRC). Therefore, the aim of this study was to assess the association of CRC and telomere length.

METHODS: In this case-control study, we measured relative telomere length from peripheral blood leukocytes (PBLs) DNA with quantitative PCR in 598 CRC patients and 2,212 healthy controls.

RESULTS: Multivariate analysis indicated that telomere length was associated with risk for CRC, and this association varied in an age-related manner; younger individuals (≤50 years of age) with longer telomeres (80-99 percentiles) had a 2-6 times higher risk of CRC, while older individuals (>50 years of age) with shortened telomeres (1-10 percentiles) had 2-12 times the risk for CRC. The risk for CRC varies with extremes in telomere length in an age-associated manner.

CONCLUSIONS: Younger individuals with longer telomeres or older individuals with shorter telomeres are at higher risk for CRC. These findings indicate that the association of PBL telomere length varies according to the age of cancer onset and that CRC is likely associated with at minimum two different mechanisms of telomere dynamics.

References

  1. Br J Cancer. 2010 Apr 13;102(8):1300-5 - PubMed
  2. Medicine (Baltimore). 2008 Sep;87(5):259-263 - PubMed
  3. Gastroenterology. 2004 Jul;127(1):9-16 - PubMed
  4. Cancer Epidemiol Biomarkers Prev. 2011 Jun;20(6):1238-50 - PubMed
  5. Cancer Epidemiol Biomarkers Prev. 2012 Oct;21(10):1807-13 - PubMed
  6. Lancet. 2003 Feb 1;361(9355):393-5 - PubMed
  7. Cancer Res. 2008 May 15;68(10):3618-23 - PubMed
  8. Clin Gastroenterol Hepatol. 2011 Jun;9(6):497-502 - PubMed
  9. N Engl J Med. 2000 Jan 13;342(2):69-77 - PubMed
  10. Carcinogenesis. 2010 Jan;31(1):9-18 - PubMed
  11. Dis Colon Rectum. 1986 May;29(5):322-5 - PubMed
  12. PLoS One. 2011;6(6):e20466 - PubMed
  13. Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2649-55 - PubMed
  14. Clin Cancer Res. 2009 Dec 1;15(23):7429-33 - PubMed
  15. Hepatogastroenterology. 2004 Jan-Feb;51(55):118-20 - PubMed
  16. Clin Chem Lab Med. 2010 Feb;48(2):259-62 - PubMed
  17. Carcinogenesis. 2005 Jul;26(7):1263-71 - PubMed
  18. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9 - PubMed
  19. Nat Genet. 2004 Sep;36(9):932-4 - PubMed
  20. Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):885-9 - PubMed
  21. Cancer Epidemiol Biomarkers Prev. 2013 Nov;22(11):2047-54 - PubMed
  22. Gut. 2012 Feb;61(2):248-54 - PubMed
  23. J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8 - PubMed
  24. Mol Cell Biol. 2000 Mar;20(5):1659-68 - PubMed
  25. Nucleic Acids Res. 2002 May 15;30(10):e47 - PubMed
  26. J Invest Dermatol. 2002 Nov;119(5):1014-9 - PubMed
  27. Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):605-13 - PubMed
  28. Nature. 1991 Apr 18;350(6319):569-73 - PubMed
  29. Hum Genet. 2011 Mar;129(3):247-53 - PubMed
  30. PLoS Genet. 2009 Feb;5(2):e1000375 - PubMed
  31. Br J Cancer. 2001 May 18;84(10):1348-53 - PubMed
  32. Am Surg. 1984 Jan;50(1):10-4 - PubMed
  33. Mech Ageing Dev. 2000 Nov 15;119(3):89-99 - PubMed
  34. Nature. 1990 Aug 30;346(6287):866-8 - PubMed
  35. Cancer Res. 2010 Apr 15;70(8):3170-6 - PubMed
  36. Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2280-2 - PubMed
  37. Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2331-43 - PubMed
  38. Cancer Sci. 2008 Jul;99(7):1385-9 - PubMed
  39. J Urol. 2007 Oct;178(4 Pt 1):1492-6 - PubMed
  40. Nature. 1990 May 31;345(6274):458-60 - PubMed
  41. Gastroenterology. 2008 Aug;135(2):410-8 - PubMed

Publication Types

Grant support