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Santos M, Gil-Brusola A, Escandell A, et al. Mycobacterium genavense Infections in a Tertiary Hospital and Reviewed Cases in Non-HIV Patients. Patholog Res Int. 2014;2014:371370doi: 10.1155/2014/371370.
Santos, M., Gil-Brusola, A., Escandell, A., Blanes, M., & Gobernado, M. (2014). Mycobacterium genavense Infections in a Tertiary Hospital and Reviewed Cases in Non-HIV Patients. Pathology research international, 2014371370. https://doi.org/10.1155/2014/371370
Santos, M, et al. "Mycobacterium genavense Infections in a Tertiary Hospital and Reviewed Cases in Non-HIV Patients." Pathology research international vol. 2014 (2014): 371370. doi: https://doi.org/10.1155/2014/371370
Santos M, Gil-Brusola A, Escandell A, Blanes M, Gobernado M. Mycobacterium genavense Infections in a Tertiary Hospital and Reviewed Cases in Non-HIV Patients. Patholog Res Int. 2014;2014:371370. doi: 10.1155/2014/371370. Epub 2014 Feb 19. PMID: 24693456; PMCID: PMC3945967.
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Patholog Res Int. 2014;2014:371370. doi: 10.1155/2014/371370. Epub 2014 Feb 19.

Mycobacterium genavense Infections in a Tertiary Hospital and Reviewed Cases in Non-HIV Patients.

Pathology research international

M Santos, A Gil-Brusola, A Escandell, M Blanes, M Gobernado

Affiliations

  1. Arevalo Baca Street 3, 46010 Valencia, Spain.
  2. Department of Microbiology, University Hospital La Fe, Avenida Campanar 21, 46009 Valencia, Spain.
  3. Infectious Diseases Unit, University Hospital La Fe, 46009 Valencia, Spain.

PMID: 24693456 PMCID: PMC3945967 DOI: 10.1155/2014/371370

Abstract

Mycobacterium genavense is a relatively new species of nontuberculous mycobacterium reported to cause disseminated infections in patients with AIDS and later on in non-HIV immunosuppressed patients. We describe clinical and laboratory features and response to therapy in 7 patients, three of them with HIV infection and four non-HIV-three organ transplant recipients and one with hyper-IgE syndrome-in Valencia, Spain, in a ten years period. We then summarize the published cases of M. avium complex infection, with invasion of peripheral blood, liver, spleen, bone marrow, lymph nodes, and lungs. In clinical samples a large number of acid-fast bacilli were observed. M. genavense grew only from liquid media and after a prolonged incubation period. Its identification was accomplished through molecular methods. Patients were treated with prolonged combinations of antimicrobial agents. There was clinical favourable outcome in 4 patients.

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