Display options
Cite
Cryer B, Mahaffey KW. Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment. J Multidiscip Healthc. 2014;7:137-46doi: 10.2147/JMDH.S54324.
Cryer, B., & Mahaffey, K. W. (2014). Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment. Journal of multidisciplinary healthcare, 7137-46. https://doi.org/10.2147/JMDH.S54324
Cryer, Byron, and Mahaffey, Kenneth W. "Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment." Journal of multidisciplinary healthcare vol. 7 (2014): 137-46. doi: https://doi.org/10.2147/JMDH.S54324
Cryer B, Mahaffey KW. Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment. J Multidiscip Healthc. 2014 Mar 03;7:137-46. doi: 10.2147/JMDH.S54324. eCollection 2014. PMID: 24741318; PMCID: PMC3970722.
Copy Download .nbib Format: NLM
Share it on

J Multidiscip Healthc. 2014 Mar 03;7:137-46. doi: 10.2147/JMDH.S54324. eCollection 2014.

Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment.

Journal of multidisciplinary healthcare

Byron Cryer, Kenneth W Mahaffey

Affiliations

  1. University of Texas Southwestern Medical School, Dallas, TX, USA.
  2. Department of Medicine, Stanford University, Stanford, CA, USA.

PMID: 24741318 PMCID: PMC3970722 DOI: 10.2147/JMDH.S54324

Abstract

Peptic ulcer disease is a major cause of morbidity and mortality in the US with more than six million diagnoses annually. Ulcers are reported as the most common cause of hospitalization for upper gastrointestinal (GI) bleeding and are often a clinical concern due to the widespread use of aspirin and nonsteroidal anti-inflammatory drugs, both of which have been shown to induce ulcer formation. The finding that Helicobacter pylori infection (independent of aspirin use) is associated with the development of ulcers led to a more thorough understanding of the causes and pathogenesis of ulcers and an improvement in therapeutic options. However, many patients infected with H. pylori are asymptomatic and remain undiagnosed. Complicating matters is a current lack of understanding of the association between aspirin use and asymptomatic ulcer formation. Low-dose aspirin prescriptions have increased, particularly for cardioprotection. Unfortunately, the GI side effects associated with aspirin therapy continue to be a major complication in both symptomatic and asymptomatic patients. These safety concerns should be important considerations in the decision to use aspirin and warrant further education. The medical community needs to continue to improve awareness of aspirin-induced GI bleeding to better equip physicians and improve care for patients requiring aspirin therapy.

Keywords: Helicobacter pylori; cardioprotection; cardiovascular disease; gastrointestinal bleeding; low-dose aspirin; ulcers

References

  1. Biochem Pharmacol. 2001 Mar 15;61(6):631-7 - PubMed
  2. Am J Infect Control. 2002 Dec;30(8):476-89 - PubMed
  3. Eur Heart J. 2011 Sep;32(18):2256-65 - PubMed
  4. Am J Forensic Med Pathol. 1994 Mar;15(1):21-7 - PubMed
  5. J Am Coll Cardiol. 2008 Feb 26;51(8):818-25 - PubMed
  6. Pediatr Med Chir. 2011 Sep-Dec;33(5-6):221-6 - PubMed
  7. Emerg Infect Dis. 2010 Sep;16(9):1410-8 - PubMed
  8. Am J Epidemiol. 1995 Mar 15;141(6):539-45 - PubMed
  9. BMJ. 2002 Jan 12;324(7329):71-86 - PubMed
  10. J Am Coll Cardiol. 2011 Jan 11;57(2):223-42 - PubMed
  11. Cleve Clin J Med. 2005 Feb;72(2):109-10, 112-3, 117-8 passim - PubMed
  12. Lancet. 2009 Oct 24;374(9699):1449-61 - PubMed
  13. N Engl J Med. 1980 Jul 17;303(3):136-8 - PubMed
  14. BMJ. 1994 Jan 22;308(6923):235-46 - PubMed
  15. BMJ. 1996 Sep 14;313(7058):652-9 - PubMed
  16. Am J Gastroenterol. 2008 Oct;103(10):2465-73 - PubMed
  17. Circulation. 2012 Aug 14;126(7):875-910 - PubMed
  18. J Gastroenterol Hepatol. 2012 Feb;27(2):195-9 - PubMed
  19. Circulation. 2010 May 11;121(18):2067-70 - PubMed
  20. Am Fam Physician. 2007 Oct 1;76(7):1005-12 - PubMed
  21. Heart. 2011 May;97(10):797-802 - PubMed
  22. Front Pharmacol. 2010 Oct 14;1:126 - PubMed
  23. QJM. 2011 Feb;104(2):133-9 - PubMed
  24. Aliment Pharmacol Ther. 1994 Apr;8(2):141-6 - PubMed
  25. Circulation. 2008 Oct 28;118(18):1894-909 - PubMed
  26. N Engl J Med. 2001 Mar 29;344(13):967-73 - PubMed
  27. J Cardiovasc Pharmacol Ther. 2006 Sep;11(3):170-6 - PubMed
  28. MMWR Suppl. 2012 Jun 15;61(2):11-8 - PubMed
  29. Gastroenterology. 2002 May;122(5):1500-11 - PubMed
  30. Gastroenterology. 2005 Oct;129(4):1171-8 - PubMed
  31. Ann Intern Med. 2010 Jan 5;152(1):1-9 - PubMed
  32. Eur Heart J. 2006 Mar;27(5):519-26 - PubMed
  33. Hepatogastroenterology. 2009 Nov-Dec;56(96):1665-9 - PubMed
  34. Lancet. 1996 Nov 23;348(9039):1413-6 - PubMed
  35. Clin Gastroenterol Hepatol. 2013 Mar;11(3):246-52.e1-5 - PubMed
  36. Br J Clin Pharmacol. 1991 Jul;32(1):77-83 - PubMed
  37. Eur Heart J. 2009 Sep;30(18):2226-32 - PubMed
  38. J Physiol Pharmacol. 2011 Aug;62(4):491-6 - PubMed
  39. Intern Emerg Med. 2012 Aug;7(4):331-5 - PubMed
  40. Aliment Pharmacol Ther. 2002 Apr;16(4):779-86 - PubMed
  41. Drugs Aging. 2012 Mar 1;29(3):233-242 - PubMed
  42. Am Heart J. 2004 Mar;147(3):463-7 - PubMed
  43. JAMA. 2005 Jan 26;293(4):427-35 - PubMed
  44. Circulation. 1998 Mar 24;97(11):1095-102 - PubMed
  45. Lancet. 1996 Mar 2;347(9001):561-8 - PubMed
  46. Circ Cardiovasc Interv. 2011 Oct 1;4(5):522-34 - PubMed
  47. Arch Intern Med. 2005 Apr 11;165(7):784-9 - PubMed
  48. Best Pract Res Clin Gastroenterol. 2010 Apr;24(2):121-32 - PubMed
  49. Am J Cardiol. 2009 Aug 1;104(3):338-42 - PubMed
  50. Thromb Haemost. 2008 Nov;100(5):752-3 - PubMed
  51. Aliment Pharmacol Ther. 2002 Nov;16(11):1945-53 - PubMed
  52. Curr Rheumatol Rep. 2001 Apr;3(2):107-11 - PubMed
  53. Scand J Gastroenterol Suppl. 1994;205:38-44 - PubMed
  54. Am J Gastroenterol. 2012 Mar;107(3):345-60; quiz 361 - PubMed
  55. Am J Gastroenterol. 2009 Mar;104(3):728-38 - PubMed
  56. Ann Med. 2008;40(6):428-36 - PubMed
  57. BMC Med. 2006 Sep 20;4:22 - PubMed
  58. World J Gastroenterol. 2006 May 14;12(18):2923-7 - PubMed
  59. Ann Intern Med. 1988 Sep 1;109(5):359-63 - PubMed
  60. Lancet. 2002 Jan 5;359(9300):14-22 - PubMed
  61. N Engl J Med. 2000 Sep 21;343(12):834-9 - PubMed
  62. Heart. 2009 Aug;95(15):1280-5 - PubMed
  63. Best Pract Res Clin Gastroenterol. 2012 Apr;26(2):125-40 - PubMed
  64. Gastrointest Endosc. 2001 Jun;53(7):853-8 - PubMed
  65. Heart. 2005 Dec;91 Suppl 5:v1-52 - PubMed
  66. Ann Intern Med. 1991 Nov 15;115(10):787-96 - PubMed
  67. Gut. 2006 Dec;55(12):1731-8 - PubMed
  68. Aliment Pharmacol Ther. 2006 May 15;23(10):1489-98 - PubMed
  69. Oral Dis. 2011 Oct;17(7):621-7 - PubMed
  70. Aliment Pharmacol Ther. 2005 Nov 1;22(9):795-801 - PubMed
  71. J Am Coll Cardiol. 2008 Oct 28;52(18):1502-17 - PubMed
  72. Lancet. 2009 May 30;373(9678):1849-60 - PubMed
  73. Ann Intern Med. 1991 Feb 15;114(4):257-63 - PubMed
  74. Ann Intern Med. 2009 Mar 17;150(6):396-404 - PubMed
  75. BMJ. 1995 Apr 1;310(6983):827-30 - PubMed
  76. J Interv Cardiol. 2005 Jun;18(3):163-6 - PubMed
  77. Circulation. 2004 Aug 3;110(5):588-636 - PubMed
  78. Curr Med Res Opin. 2007 Jan;23(1):163-73 - PubMed
  79. BMC Clin Pharmacol. 2001;1:1 - PubMed
  80. Scand J Gastroenterol. 2007 Dec;42(12):1395-403 - PubMed
  81. Br J Surg. 1988 Nov;75(11):1112-4 - PubMed
  82. Dig Dis Sci. 2005 Jan;50(1):78-80 - PubMed
  83. N Engl J Med. 2002 Jun 27;346(26):2033-8 - PubMed
  84. Eur J Intern Med. 2010 Dec;21(6):484-9 - PubMed
  85. Scand J Gastroenterol. 2011 Jul;46(7-8):803-9 - PubMed
  86. Circulation. 2010 Jun 22;121(24):2694-701 - PubMed
  87. Am J Gastroenterol. 2011 Feb;106(2):272-7 - PubMed

Publication Types