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Pedunculopontine arousal system physiology - Implications for insomnia.

Sleep science (Sao Paulo, Brazil)

Garcia-Rill E, Luster B, Mahaffey S, Bisagno V, Urbano FJ.
PMID: 26483950
Sleep Sci. 2015 Apr-Jun;8(2):92-9. doi: 10.1016/j.slsci.2015.06.002. Epub 2015 Jul 10.

We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We...

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Garcia-Rill E, Luster B, Mahaffey S, et al. Pedunculopontine arousal system physiology - Implications for insomnia. Sleep Sci. 2015;8(2):92-9doi: 10.1016/j.slsci.2015.06.002.
Garcia-Rill, E., Luster, B., Mahaffey, S., Bisagno, V., & Urbano, F. J. (2015). Pedunculopontine arousal system physiology - Implications for insomnia. Sleep science (Sao Paulo, Brazil), 8(2), 92-9. https://doi.org/10.1016/j.slsci.2015.06.002
Garcia-Rill, Edgar, et al. "Pedunculopontine arousal system physiology - Implications for insomnia." Sleep science (Sao Paulo, Brazil) vol. 8,2 (2015): 92-9. doi: https://doi.org/10.1016/j.slsci.2015.06.002
Garcia-Rill E, Luster B, Mahaffey S, Bisagno V, Urbano FJ. Pedunculopontine arousal system physiology - Implications for insomnia. Sleep Sci. 2015 Apr-Jun;8(2):92-9. doi: 10.1016/j.slsci.2015.06.002. Epub 2015 Jul 10. PMID: 26483950; PMCID: PMC4608886.
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Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses.

Veterinary clinical pathology

Henson KL, Alleman AR, Kelley LC, Mahaffey EA.
PMID: 12070809
Vet Clin Pathol. 2000;29(2):40-46. doi: 10.1111/j.1939-165x.2000.tb00396.x.

Immunohistochemical techniques were used to examine 29 cases of equine lymphoma for estrogen receptor (ER) and progesterone receptor (PR) expression. The lymphomas examined included T-cell-rich large B-cell lymphomas, B-cell neoplasms, and T-cell lymphomas. The individual cases were also classified...

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Henson KL, Alleman AR, Kelley LC, et al. Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses. Vet Clin Pathol. 2000;29(2):40-46doi: 10.1111/j.1939-165x.2000.tb00396.x.
Henson, K. L., Alleman, A. R., Kelley, L. C., & Mahaffey, E. A. (2000). Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses. Veterinary clinical pathology, 29(2), 40-46. https://doi.org/10.1111/j.1939-165x.2000.tb00396.x
Henson, Kristin L., et al. "Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses." Veterinary clinical pathology vol. 29,2 (2000): 40-46. doi: https://doi.org/10.1111/j.1939-165x.2000.tb00396.x
Henson KL, Alleman AR, Kelley LC, Mahaffey EA. Immunohistochemical characterization of estrogen and progesterone receptors in lymphoma of horses. Vet Clin Pathol. 2000;29(2):40-46. doi: 10.1111/j.1939-165x.2000.tb00396.x. PMID: 12070809.
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Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment.

Journal of multidisciplinary healthcare

Cryer B, Mahaffey KW.
PMID: 24741318
J Multidiscip Healthc. 2014 Mar 03;7:137-46. doi: 10.2147/JMDH.S54324. eCollection 2014.

Peptic ulcer disease is a major cause of morbidity and mortality in the US with more than six million diagnoses annually. Ulcers are reported as the most common cause of hospitalization for upper gastrointestinal (GI) bleeding and are often...

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Cryer B, Mahaffey KW. Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment. J Multidiscip Healthc. 2014;7:137-46doi: 10.2147/JMDH.S54324.
Cryer, B., & Mahaffey, K. W. (2014). Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment. Journal of multidisciplinary healthcare, 7137-46. https://doi.org/10.2147/JMDH.S54324
Cryer, Byron, and Mahaffey, Kenneth W. "Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment." Journal of multidisciplinary healthcare vol. 7 (2014): 137-46. doi: https://doi.org/10.2147/JMDH.S54324
Cryer B, Mahaffey KW. Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment. J Multidiscip Healthc. 2014 Mar 03;7:137-46. doi: 10.2147/JMDH.S54324. eCollection 2014. PMID: 24741318; PMCID: PMC3970722.
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Cardiac Safety Research Consortium (CSRC): Cardiovascular Safety and Adverse Event Case Report Forms.

Therapeutic innovation & regulatory science

Sabol ME, Finkle J, Krucoff M, Stockbridge N, Parkhill N, Shinagawa K, Mahaffey K, Tcheng J, Lenihan D, Melloni C, Todaro T, Michelson E, Munley J, Zander J, Oh R.
PMID: 30222439
Ther Innov Regul Sci. 2015 Jul;49(4):511-513. doi: 10.1177/2168479014567319.

Detection of off-target cardiovascular (CV) effects remains a significant challenge to drug development. Documentation of CV events in non-CV trials is often inadequate to interpret imbalances between treatment arms, which may lead to concerns about potential CV safety "signals."...

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Sabol ME, Finkle J, Krucoff M, et al. Cardiac Safety Research Consortium (CSRC): Cardiovascular Safety and Adverse Event Case Report Forms. Ther Innov Regul Sci. 2015;49(4):511-513doi: 10.1177/2168479014567319.
Sabol, M. E., Finkle, J., Krucoff, M., Stockbridge, N., Parkhill, N., Shinagawa, K., Mahaffey, K., Tcheng, J., Lenihan, D., Melloni, C., Todaro, T., Michelson, E., Munley, J., Zander, J., & Oh, R. (2015). Cardiac Safety Research Consortium (CSRC): Cardiovascular Safety and Adverse Event Case Report Forms. Therapeutic innovation & regulatory science, 49(4), 511-513. https://doi.org/10.1177/2168479014567319
Sabol, Mary Elizabeth, et al. "Cardiac Safety Research Consortium (CSRC): Cardiovascular Safety and Adverse Event Case Report Forms." Therapeutic innovation & regulatory science vol. 49,4 (2015): 511-513. doi: https://doi.org/10.1177/2168479014567319
Sabol ME, Finkle J, Krucoff M, Stockbridge N, Parkhill N, Shinagawa K, Mahaffey K, Tcheng J, Lenihan D, Melloni C, Todaro T, Michelson E, Munley J, Zander J, Oh R. Cardiac Safety Research Consortium (CSRC): Cardiovascular Safety and Adverse Event Case Report Forms. Ther Innov Regul Sci. 2015 Jul;49(4):511-513. doi: 10.1177/2168479014567319. PMID: 30222439.
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Put Me Back In Coach! Concussion and Return to Play.

Missouri medicine

Mahaffey BL.
PMID: 30228549
Mo Med. 2017 Mar-Apr;114(2):96-97.

No abstract available.

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Mahaffey BL. Put Me Back In Coach! Concussion and Return to Play. Mo Med. 2017;114(2):96-97
Mahaffey, B. L. (2017). Put Me Back In Coach! Concussion and Return to Play. Missouri medicine, 114(2), 96-97.
Mahaffey, Brian L. "Put Me Back In Coach! Concussion and Return to Play." Missouri medicine vol. 114,2 (2017): 96-97.
Mahaffey BL. Put Me Back In Coach! Concussion and Return to Play. Mo Med. 2017 Mar-Apr;114(2):96-97. PMID: 30228549; PMCID: PMC6140015.
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Association of Body Mass Index With Care and Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry.

JACC. Clinical electrophysiology

Pandey A, Gersh BJ, McGuire DK, Shrader P, Thomas L, Kowey PR, Mahaffey KW, Hylek E, Sun S, Burton P, Piccini J, Peterson E, Fonarow GC.
PMID: 29766895
JACC Clin Electrophysiol. 2016 Jun;2(3):355-363. doi: 10.1016/j.jacep.2015.12.001. Epub 2015 Dec 09.

OBJECTIVES: This study sought to determine the association between body mass index (BMI) and clinical outcomes among patients with prevalent atrial fibrillation (AF).BACKGROUND: Higher BMI is an independent risk factor for incident AF. However, its impact on management strategies...

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Pandey A, Gersh BJ, McGuire DK, et al. Association of Body Mass Index With Care and Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry. JACC Clin Electrophysiol. 2015;2(3):355-363doi: 10.1016/j.jacep.2015.12.001.
Pandey, A., Gersh, B. J., McGuire, D. K., Shrader, P., Thomas, L., Kowey, P. R., Mahaffey, K. W., Hylek, E., Sun, S., Burton, P., Piccini, J., Peterson, E., & Fonarow, G. C. (2016). Association of Body Mass Index With Care and Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry. JACC. Clinical electrophysiology, 2(3), 355-363. https://doi.org/10.1016/j.jacep.2015.12.001
Pandey, Ambarish, et al. "Association of Body Mass Index With Care and Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry." JACC. Clinical electrophysiology vol. 2,3 (2016): 355-363. doi: https://doi.org/10.1016/j.jacep.2015.12.001
Pandey A, Gersh BJ, McGuire DK, Shrader P, Thomas L, Kowey PR, Mahaffey KW, Hylek E, Sun S, Burton P, Piccini J, Peterson E, Fonarow GC. Association of Body Mass Index With Care and Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry. JACC Clin Electrophysiol. 2016 Jun;2(3):355-363. doi: 10.1016/j.jacep.2015.12.001. Epub 2015 Dec 09. PMID: 29766895.
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Prominence of Analytical Chemistry in Modern-Day Healthcare: Current Medical Discoveries, Student Perspectives, and Systems Thinking.

Analytical chemistry

Mahaffey AL.
PMID: 33689291
Anal Chem. 2021 Mar 23;93(11):4775-4781. doi: 10.1021/acs.analchem.1c00041. Epub 2021 Mar 09.

In the course of two years (2018 and 2020), anatomists and medical professionals became wonderstruck by two significant organ

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Mahaffey AL. Prominence of Analytical Chemistry in Modern-Day Healthcare: Current Medical Discoveries, Student Perspectives, and Systems Thinking. Anal Chem. 2021;93(11):4775-4781doi: 10.1021/acs.analchem.1c00041.
Mahaffey, A. L. (2021). Prominence of Analytical Chemistry in Modern-Day Healthcare: Current Medical Discoveries, Student Perspectives, and Systems Thinking. Analytical chemistry, 93(11), 4775-4781. https://doi.org/10.1021/acs.analchem.1c00041
Mahaffey, Angela L. "Prominence of Analytical Chemistry in Modern-Day Healthcare: Current Medical Discoveries, Student Perspectives, and Systems Thinking." Analytical chemistry vol. 93,11 (2021): 4775-4781. doi: https://doi.org/10.1021/acs.analchem.1c00041
Mahaffey AL. Prominence of Analytical Chemistry in Modern-Day Healthcare: Current Medical Discoveries, Student Perspectives, and Systems Thinking. Anal Chem. 2021 Mar 23;93(11):4775-4781. doi: 10.1021/acs.analchem.1c00041. Epub 2021 Mar 09. PMID: 33689291.
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Pharmacotherapy for diabetes and stroke risk: Results from ROCKET AF.

Heart rhythm O2

Ugowe FE, Hellkamp AS, Wang A, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Singer DE, Patel MR, Piccini JP.
PMID: 34337571
Heart Rhythm O2. 2021 Apr 20;2(3):215-222. doi: 10.1016/j.hroo.2021.04.001. eCollection 2021 Jun.

BACKGROUND: Insulin use may be a better predictor of stroke risk and morbidity and mortality than diabetes in patients with atrial fibrillation (AF).OBJECTIVES: Determine if the increased risk of stroke observed in patients with AF and diabetes is restricted...

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Ugowe FE, Hellkamp AS, Wang A, et al. Pharmacotherapy for diabetes and stroke risk: Results from ROCKET AF. Heart Rhythm O2. 2021;2(3):215-222doi: 10.1016/j.hroo.2021.04.001.
Ugowe, F. E., Hellkamp, A. S., Wang, A., Becker, R. C., Berkowitz, S. D., Breithardt, G., Fox, K. A. A., Halperin, J. L., Hankey, G. J., Mahaffey, K. W., Nessel, C. C., Singer, D. E., Patel, M. R., Piccini, J. P. (2021). Pharmacotherapy for diabetes and stroke risk: Results from ROCKET AF. Heart rhythm O2, 2(3), 215-222. https://doi.org/10.1016/j.hroo.2021.04.001
Ugowe, Francis E, et al. "Pharmacotherapy for diabetes and stroke risk: Results from ROCKET AF." Heart rhythm O2 vol. 2,3 (2021): 215-222. doi: https://doi.org/10.1016/j.hroo.2021.04.001
Ugowe FE, Hellkamp AS, Wang A, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Singer DE, Patel MR, Piccini JP. Pharmacotherapy for diabetes and stroke risk: Results from ROCKET AF. Heart Rhythm O2. 2021 Apr 20;2(3):215-222. doi: 10.1016/j.hroo.2021.04.001. eCollection 2021 Jun. PMID: 34337571; PMCID: PMC8322824.
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Angiotensin II-induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-alpha type 1 receptor.

Physiological reports

Majid DSA, Mahaffey E, Castillo A, Prieto MC, Navar LG.
PMID: 34427402
Physiol Rep. 2021 Aug;9(16):e14990. doi: 10.14814/phy2.14990.

In hypertension induced by angiotensin II (AngII) administration with high salt (HS) intake, intrarenal angiotensinogen (AGT) and tumor necrosis factor-alpha (TNF-α) levels increase. However, TNF-α has been shown to suppress AGT formation in cultured renal proximal tubular cells. We...

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Majid DSA, Mahaffey E, Castillo A, et al. Angiotensin II-induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-alpha type 1 receptor. Physiol Rep. 2021;9(16):e14990doi: 10.14814/phy2.14990.
Majid, D. S. A., Mahaffey, E., Castillo, A., Prieto, M. C., & Navar, L. G. (2021). Angiotensin II-induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-alpha type 1 receptor. Physiological reports, 9(16), e14990. https://doi.org/10.14814/phy2.14990
Majid, Dewan S A, et al. "Angiotensin II-induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-alpha type 1 receptor." Physiological reports vol. 9,16 (2021): e14990. doi: https://doi.org/10.14814/phy2.14990
Majid DSA, Mahaffey E, Castillo A, Prieto MC, Navar LG. Angiotensin II-induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-alpha type 1 receptor. Physiol Rep. 2021 Aug;9(16):e14990. doi: 10.14814/phy2.14990. PMID: 34427402; PMCID: PMC8383705.
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Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis.

Stroke

Zhou Z, Jardine MJ, Li Q, Neuen BL, Cannon CP, de Zeeuw D, Edwards R, Levin A, Mahaffey KW, Perkovic V, Neal B, Lindley RI.
PMID: 33874750
Stroke. 2021 May;52(5):1545-1556. doi: 10.1161/STROKEAHA.120.031623. Epub 2021 Apr 20.

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter...

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Zhou Z, Jardine MJ, Li Q, et al. Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis. Stroke. 2021;52(5):1545-1556doi: 10.1161/STROKEAHA.120.031623.
Zhou, Z., Jardine, M. J., Li, Q., Neuen, B. L., Cannon, C. P., de Zeeuw, D., Edwards, R., Levin, A., Mahaffey, K. W., Perkovic, V., Neal, B., Lindley, R. I. (2021). Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis. Stroke, 52(5), 1545-1556. https://doi.org/10.1161/STROKEAHA.120.031623
Zhou, Zien, et al. "Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis." Stroke vol. 52,5 (2021): 1545-1556. doi: https://doi.org/10.1161/STROKEAHA.120.031623
Zhou Z, Jardine MJ, Li Q, Neuen BL, Cannon CP, de Zeeuw D, Edwards R, Levin A, Mahaffey KW, Perkovic V, Neal B, Lindley RI. Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis. Stroke. 2021 May;52(5):1545-1556. doi: 10.1161/STROKEAHA.120.031623. Epub 2021 Apr 20. PMID: 33874750; PMCID: PMC8078131.
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Clinical Utility of KidneyIntelX in Early Stages of Diabetic Kidney Disease in the CANVAS Trial.

American journal of nephrology

Lam D, Nadkarni GN, Mosoyan G, Neal B, Mahaffey KW, Rosenthal N, Hansen MK, Heerspink HJL, Fleming F, Coca SG.
PMID: 35016188
Am J Nephrol. 2022 Jan 11;1-11. doi: 10.1159/000519920. Epub 2022 Jan 11.

INTRODUCTION: KidneyIntelX is a composite risk score, incorporating biomarkers and clinical variables for predicting progression of diabetic kidney disease (DKD). The utility of this score in the context of sodium glucose co-transporter 2 inhibitors and how changes in the...

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Lam D, Nadkarni GN, Mosoyan G, et al. Clinical Utility of KidneyIntelX in Early Stages of Diabetic Kidney Disease in the CANVAS Trial. Am J Nephrol. 2022;1-11doi: 10.1159/000519920.
Lam, D., Nadkarni, G. N., Mosoyan, G., Neal, B., Mahaffey, K. W., Rosenthal, N., Hansen, M. K., Heerspink, H. J. L., Fleming, F., & Coca, S. G. (2022). Clinical Utility of KidneyIntelX in Early Stages of Diabetic Kidney Disease in the CANVAS Trial. American journal of nephrology, 1-11. https://doi.org/10.1159/000519920
Lam, David, et al. "Clinical Utility of KidneyIntelX in Early Stages of Diabetic Kidney Disease in the CANVAS Trial." American journal of nephrology vol. (2022): 1-11. doi: https://doi.org/10.1159/000519920
Lam D, Nadkarni GN, Mosoyan G, Neal B, Mahaffey KW, Rosenthal N, Hansen MK, Heerspink HJL, Fleming F, Coca SG. Clinical Utility of KidneyIntelX in Early Stages of Diabetic Kidney Disease in the CANVAS Trial. Am J Nephrol. 2022 Jan 11;1-11. doi: 10.1159/000519920. Epub 2022 Jan 11. PMID: 35016188.
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Barriers and facilitators to postoperative pain management in Rwanda from the perspective of health care providers: A contextualization of the theory of planned behavior.

Canadian journal of pain = Revue canadienne de la douleur

Nyirigira G, Wilson RA, VanDenKerkhof EG, Goldstein DH, Twagirumugabe T, Mahaffey R, Parlow J, Johnson AP.
PMID: 35005369
Can J Pain. 2018 Apr 12;2(1):87-102. doi: 10.1080/24740527.2018.1451251. eCollection 2018.

AIMS: Identify opportunities to improve knowledge translation for post-operative pain management in Rwanda by exploring clinician and environmental factors affecting this practice.METHODS: The theory of planned behavior (TPB) guided development of a questionnaire to measure intent to assess and...

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Nyirigira G, Wilson RA, VanDenKerkhof EG, et al. Barriers and facilitators to postoperative pain management in Rwanda from the perspective of health care providers: A contextualization of the theory of planned behavior. Can J Pain. 2018;2(1):87-102doi: 10.1080/24740527.2018.1451251.
Nyirigira, G., Wilson, R. A., VanDenKerkhof, E. G., Goldstein, D. H., Twagirumugabe, T., Mahaffey, R., Parlow, J., & Johnson, A. P. (2018). Barriers and facilitators to postoperative pain management in Rwanda from the perspective of health care providers: A contextualization of the theory of planned behavior. Canadian journal of pain = Revue canadienne de la douleur, 2(1), 87-102. https://doi.org/10.1080/24740527.2018.1451251
Nyirigira, Gaston, et al. "Barriers and facilitators to postoperative pain management in Rwanda from the perspective of health care providers: A contextualization of the theory of planned behavior." Canadian journal of pain = Revue canadienne de la douleur vol. 2,1 (2018): 87-102. doi: https://doi.org/10.1080/24740527.2018.1451251
Nyirigira G, Wilson RA, VanDenKerkhof EG, Goldstein DH, Twagirumugabe T, Mahaffey R, Parlow J, Johnson AP. Barriers and facilitators to postoperative pain management in Rwanda from the perspective of health care providers: A contextualization of the theory of planned behavior. Can J Pain. 2018 Apr 12;2(1):87-102. doi: 10.1080/24740527.2018.1451251. eCollection 2018. PMID: 35005369; PMCID: PMC8730569.
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Showing 1 to 12 of 122 entries