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Guimarães LO, de Andrade FA, Bono GF, et al. Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids. Genet Mol Biol. 2013;37(1):1-6doi: 10.1590/s1415-47572014000100003.
Guimarães, L. O., de Andrade, F. A., Bono, G. F., Setoguchi, T. E., Brandão, M. B., Chautard-Freire-Maia, E. A., Dos Santos, I. C., Picheth, G., Faria, A. C., Réa, R. R., Souza, R. L., & Furtado-Alle, L. (2014). Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids. Genetics and molecular biology, 37(1), 1-6. https://doi.org/10.1590/s1415-47572014000100003
Guimarães, Larissa O, et al. "Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids." Genetics and molecular biology vol. 37,1 (2014): 1-6. doi: https://doi.org/10.1590/s1415-47572014000100003
Guimarães LO, de Andrade FA, Bono GF, Setoguchi TE, Brandão MB, Chautard-Freire-Maia EA, Dos Santos IC, Picheth G, Faria AC, Réa RR, Souza RL, Furtado-Alle L. Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids. Genet Mol Biol. 2014 Mar;37(1):1-6. doi: 10.1590/s1415-47572014000100003. Epub 2013 Feb 28. PMID: 24688284; PMCID: PMC3958315.
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Genet Mol Biol. 2014 Mar;37(1):1-6. doi: 10.1590/s1415-47572014000100003. Epub 2013 Feb 28.

Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids.

Genetics and molecular biology

Larissa O Guimarães, Fabiana A de Andrade, Gleyse F Bono, Thaís E Setoguchi, Mariana B Brandão, Eleidi A Chautard-Freire-Maia, Izabella C R Dos Santos, Geraldo Picheth, Ana Cristina R de A Faria, Rosângela R Réa, Ricardo L R Souza, Lupe Furtado-Alle

Affiliations

  1. Paboratório de Polimorfismos e Ligação, Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil .
  2. Laboratório de Bioquímica Clínica, Setor de Ciências da Saúde, Universidade Federal do Paraná, Curitiba, PR, Brazil .
  3. Unidade de Diabetes do Serviço de Endocrinologia e Metabolismo, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil .

PMID: 24688284 PMCID: PMC3958315 DOI: 10.1590/s1415-47572014000100003

Abstract

Many conditions interfere with butyrylcholinesterase (BChE) activity, e.g., pregnancy or presence of the BCHE gene variant -116A can decrease activity whereas obesity and types I and II diabetes mellitus can increase activity. In this study, we examined BChE activity, -116A and 1615A BCHE gene variants, and anthropometric and biochemical variables associated with diabetes in patients with gestational diabetes mellitus (GDM) and in healthy pregnant women. BChE activity was measured spectrophotometrically using propionylthiocholine as substrate and genotyping of the -116 and 1615 sites of the BCHE gene was done with a TaqMan SNP genotyping assay. Three groups were studied: 150 patients with GDM, 295 healthy pregnant women and 156 non-pregnant healthy women. Mean BChE activity was significantly lower in healthy pregnant women than in women from the general population and was further reduced in GDM patients. BChE activity was significantly reduced in carriers of -116A in GDM patients and healthy pregnant women. Although GDM patients had a significantly higher mean body mass index (BMI) and triglycerides than healthy pregnant women, they had lower mean BChE activity, suggesting that the lowering effect of GDM on BChE activity was stronger than the characteristic enhancing effect of increased BMI and triglycerides.

Keywords: 1615A variant; butyrylcholinesterase (BChE); gestational diabetes mellitus; −116A variant

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