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Decourt B, Mobley W, Reiman E, et al. Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome. J Alzheimers Dis Parkinsonism. 2013;002doi: 10.4172/2161-0460.S7-002.
Decourt, B., Mobley, W., Reiman, E., Shah, R. J., & Sabbagh, M. N. (2013). Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome. Journal of Alzheimer's disease & Parkinsonism, 002. https://doi.org/10.4172/2161-0460.S7-002
Decourt, Boris, et al. "Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome." Journal of Alzheimer's disease & Parkinsonism vol. (2013): 002. doi: https://doi.org/10.4172/2161-0460.S7-002
Decourt B, Mobley W, Reiman E, Shah RJ, Sabbagh MN. Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome. J Alzheimers Dis Parkinsonism. 2013 Mar 20;002. doi: 10.4172/2161-0460.S7-002. PMID: 24782952; PMCID: PMC4000700.
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J Alzheimers Dis Parkinsonism. 2013 Mar 20;002. doi: 10.4172/2161-0460.S7-002.

Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome.

Journal of Alzheimer's disease & Parkinsonism

Boris Decourt, William Mobley, Eric Reiman, Raj Jatin Shah, Marwan N Sabbagh

Affiliations

  1. Banner Sun Health Research Institute, Sun City AZ, USA.
  2. University of California-San Diego, San Diego CA, USA.
  3. Banner Alzheimer's Institute, Phoenix AZ, USA.

PMID: 24782952 PMCID: PMC4000700 DOI: 10.4172/2161-0460.S7-002

Abstract

Down syndrome is one of the most common genetic conditions occurring in one in 700 live births. The trisomy of chromosome 21 causes over-expression of APP which in turn is indicated in the increased production of Aβ associated with AD. This makes DS the most common presenile form of AD exceeding PS1 and PS2 FAD. Since a majority of DS individuals develop dementia, it is important to examine whether DS and sporadic AD share common features, for example, to anticipate shared treatments in the future. Here we explore commonalities and differences for secretases and endosomal pathways in DS and AD.

Keywords: Down syndrome; Over-expression; Trisomy

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