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Miyauchi A, Kudo T, Hirokawa M, et al. Ki-67 labeling index is a predictor of postoperative persistent disease and cancer growth and a prognostic indicator in papillary thyroid carcinoma. Eur Thyroid J. 2013;2(1):57-64doi: 10.1159/000347148.
Miyauchi, A., Kudo, T., Hirokawa, M., Ito, Y., Kihara, M., Higashiyama, T., Yabuta, T., Masuoka, H., Shindo, H., Kobayashi, K., & Miya, A. (2013). Ki-67 labeling index is a predictor of postoperative persistent disease and cancer growth and a prognostic indicator in papillary thyroid carcinoma. European thyroid journal, 2(1), 57-64. https://doi.org/10.1159/000347148
Miyauchi, Akira, et al. "Ki-67 labeling index is a predictor of postoperative persistent disease and cancer growth and a prognostic indicator in papillary thyroid carcinoma." European thyroid journal vol. 2,1 (2013): 57-64. doi: https://doi.org/10.1159/000347148
Miyauchi A, Kudo T, Hirokawa M, Ito Y, Kihara M, Higashiyama T, Yabuta T, Masuoka H, Shindo H, Kobayashi K, Miya A. Ki-67 labeling index is a predictor of postoperative persistent disease and cancer growth and a prognostic indicator in papillary thyroid carcinoma. Eur Thyroid J. 2013 Mar;2(1):57-64. doi: 10.1159/000347148. Epub 2013 Feb 16. PMID: 24783039; PMCID: PMC3821500.
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Eur Thyroid J. 2013 Mar;2(1):57-64. doi: 10.1159/000347148. Epub 2013 Feb 16.

Ki-67 labeling index is a predictor of postoperative persistent disease and cancer growth and a prognostic indicator in papillary thyroid carcinoma.

European thyroid journal

Akira Miyauchi, Takumi Kudo, Mitsuyoshi Hirokawa, Yasuhiro Ito, Minoru Kihara, Takuya Higashiyama, Tomonori Yabuta, Hiroo Masuoka, Hisakazu Shindo, Kaoru Kobayashi, Akihiro Miya

Affiliations

  1. Department of Surgery, Kobe, Japan.
  2. Department of Internal Medicine, Kobe, Japan.
  3. Department of Pathology, Kuma Hospital, Kobe, Japan.

PMID: 24783039 PMCID: PMC3821500 DOI: 10.1159/000347148

Abstract

BACKGROUND: We previously reported that the Ki-67 labeling index (LI) in primary tumors and the thyroglobulin (Tg)-doubling time (DT) were potent prognostic indicators in patients with papillary thyroid carcinoma (PTC).

OBJECTIVES: To elucidate the relationship between these two factors.

METHODS: A total of 390 patients with PTC who underwent total thyroidectomy between 1998 and 2004 and in whom the Tg-DT was calculated were enrolled. We determined the Ki-67 LI in primary tumors and compared these values with the patients' clinicopathological factors, postoperative Tg status, Tg-DT, and prognosis. Tg status was categorized by postoperative serum Tg values: biochemically persistent disease (BPD), equivocal state, and biochemical remission.

RESULTS: The Ki-67 LI was ≤5% in 312 patients (80%), 5%-10% in 48 patients (12%), and >10% in 30 patients (8%). Ki-67 LI was significantly associated with BPD (p < 0.0001). The proportion of BPD patients increased with the higher Ki-67 LI category: 24, 67, and 87%, respectively. The Ki-67 LI had a significant inverse correlation with the Tg-DT (Spearman's ρ = -0.5267, p < 0.0001). Of the 378 patients without distant metastasis at surgery, 68 patients had recurrence, and 6 of the 390 patients died of PTC during the follow-up (mean 88 months). On multivariate analyses, the Ki-67 LI remained an independent predictor of disease-free survival and disease-specific survival when Tg-DT and Tg status were excluded from the analyses.

CONCLUSIONS: Evaluation of the Ki-67 LI in primary tumors may allow the prediction of the postoperative Tg status, Tg-DT and prognosis of patients with PTC. Published by S. Karger AG, Basel.

Keywords: Biochemically persistent disease; Ki-67 labeling index; Papillary thyroid carcinoma; Prognosis; Thyroglobulin-doubling time

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