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Mikami S, Tateishi R, Hagiwara S, et al. Tumor markers are more useful in patients undergoing surveillance for hepatocellular carcinoma with unreliable results by ultrasonography. Hepatol Res. 2014;45(4):415-22doi: 10.1111/hepr.12365.
Mikami, S., Tateishi, R., Hagiwara, S., Sato, M., Minami, T., Uchino, K., Enooku, K., Sato, T., Nakagawa, H., Masuzaki, R., Asaoka, Y., Kondo, Y., Shiina, S., Ikeda, H., Omata, M., Yoshida, H., & Koike, K. (2015). Tumor markers are more useful in patients undergoing surveillance for hepatocellular carcinoma with unreliable results by ultrasonography. Hepatology research : the official journal of the Japan Society of Hepatology, 45(4), 415-22. https://doi.org/10.1111/hepr.12365
Mikami, Shintaro, et al. "Tumor markers are more useful in patients undergoing surveillance for hepatocellular carcinoma with unreliable results by ultrasonography." Hepatology research : the official journal of the Japan Society of Hepatology vol. 45,4 (2015): 415-22. doi: https://doi.org/10.1111/hepr.12365
Mikami S, Tateishi R, Hagiwara S, Sato M, Minami T, Uchino K, Enooku K, Sato T, Nakagawa H, Masuzaki R, Asaoka Y, Kondo Y, Shiina S, Ikeda H, Omata M, Yoshida H, Koike K. Tumor markers are more useful in patients undergoing surveillance for hepatocellular carcinoma with unreliable results by ultrasonography. Hepatol Res. 2015 Apr;45(4):415-22. doi: 10.1111/hepr.12365. Epub 2014 Jun 19. PMID: 24861870.
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Hepatol Res. 2015 Apr;45(4):415-22. doi: 10.1111/hepr.12365. Epub 2014 Jun 19.

Tumor markers are more useful in patients undergoing surveillance for hepatocellular carcinoma with unreliable results by ultrasonography.

Hepatology research : the official journal of the Japan Society of Hepatology

Shintaro Mikami, Ryosuke Tateishi, Shu Hagiwara, Masaya Sato, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Takahisa Sato, Hayato Nakagawa, Ryota Masuzaki, Yoshinari Asaoka, Yuji Kondo, Shuichiro Shiina, Hitoshi Ikeda, Masao Omata, Haruhiko Yoshida, Kazuhiko Koike

Affiliations

  1. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

PMID: 24861870 DOI: 10.1111/hepr.12365

Abstract

AIM: The objectives of this study was to evaluate the utility of tumor markers in hepatocellular carcinoma (HCC) surveillance based on the reliability of ultrasonography.

METHODS: We analyzed 313 patients with HCC detected through a surveillance program using ultrasonography combined with three tumor markers from February 2000 to December 2010. The patients were categorized into two groups based on the triggering event: the US group (n = 281) in which a tumor was first detected using ultrasonography and the TM group (n = 32) in which elevated tumor markers led to the diagnosis of a tumor that was undetected using ultrasonography. The reliability of ultrasonography was scored on a 4-point scale based on three items (coarseness of liver parenchyma, patient obesity and liver atrophy). Additionally, patient survival was assessed using the Kaplan-Meier method and log-rank test.

RESULTS: The median tumor size was 20 mm (interquartile range, 15-24). The reliability of ultrasonography was evaluated as good in 208 (66.5%), satisfactory in 80 (8.0%), poor in 21 (6.7%) and unsatisfactory in four (1.2%) patients. The proportion of patients in the TM group increased significantly according to the score, from 7.2% to 25.0% (P = 0.01). The survival rates of patients at 3 and 5 years were 83.7% and 57.2% in the US group, and 79.3% and 59.4% in the TM group, respectively (P = 0.98).

CONCLUSION: Tumor markers may play a diagnostic role in patients with unreliable ultrasonography results. The survival of patients diagnosed by elevated tumor markers was not significantly different from those diagnosed by ultrasonography.

© 2014 The Japan Society of Hepatology.

Keywords: hepatocellular carcinoma; surveillance; tumor marker; ultrasonography

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