Display options
Cite
Harada K, Akai Y, Sumida K, et al. Significance of renal biopsy in patients with presumed diabetic nephropathy. J Diabetes Investig. 2012;4(1):88-93doi: 10.1111/j.2040-1124.2012.00233.x.
Harada, K., Akai, Y., Sumida, K., Yoshikawa, M., Takahashi, H., Yamaguchi, Y., Kubo, A., Iwano, M., & Saito, Y. (2013). Significance of renal biopsy in patients with presumed diabetic nephropathy. Journal of diabetes investigation, 4(1), 88-93. https://doi.org/10.1111/j.2040-1124.2012.00233.x
Harada, Koji, et al. "Significance of renal biopsy in patients with presumed diabetic nephropathy." Journal of diabetes investigation vol. 4,1 (2013): 88-93. doi: https://doi.org/10.1111/j.2040-1124.2012.00233.x
Harada K, Akai Y, Sumida K, Yoshikawa M, Takahashi H, Yamaguchi Y, Kubo A, Iwano M, Saito Y. Significance of renal biopsy in patients with presumed diabetic nephropathy. J Diabetes Investig. 2013 Jan 29;4(1):88-93. doi: 10.1111/j.2040-1124.2012.00233.x. Epub 2012 Aug 10. PMID: 24843636; PMCID: PMC4019293.
Copy Download .nbib Format: NLM
Share it on

J Diabetes Investig. 2013 Jan 29;4(1):88-93. doi: 10.1111/j.2040-1124.2012.00233.x. Epub 2012 Aug 10.

Significance of renal biopsy in patients with presumed diabetic nephropathy.

Journal of diabetes investigation

Koji Harada, Yasuhiro Akai, Koichi Sumida, Mikiko Yoshikawa, Hiroki Takahashi, Yukinari Yamaguchi, Atsushi Kubo, Masayuki Iwano, Yoshihiko Saito

Affiliations

  1. Department of Nephrology Rakuwakai-Otowa Hospital Yamashina Kyoto Japan ; First Department of Internal Medicine Nara Medical University Kashihara Nara Japan.
  2. First Department of Internal Medicine Nara Medical University Kashihara Nara Japan.
  3. Department of Nephrology Rakuwakai-Otowa Hospital Yamashina Kyoto Japan.
  4. Division of Nephrology Department of General Medicine School of Medicine Faculty of Medical Sciences University of Fukui Yoshida-gun Fukui Japan.

PMID: 24843636 PMCID: PMC4019293 DOI: 10.1111/j.2040-1124.2012.00233.x

Abstract

AIMS/INTRODUCTION: Patients with diabetic nephropathy (DN) typically show varying degrees of proteinuria and renal impairment. Because these clinical signs are frequently observed in other glomerulopathies, renal biopsy is required to make a definitive diagnosis of DN. We carried out the present study to evaluate the significance of renal biopsy for patients who have been presumptively diagnosed with DN.

MATERIALS AND METHODS: A total of 55 patients with type 2 diabetes mellitus (DM), and proteinuria, hematuria and/or renal impairment were enrolled in this study.

RESULTS: Renal biopsy showed that just 30 patients (54.5%) were histologically diagnosed with DN. Fasting plasma glucose and glycated hemoglobin levels were associated with the presence of DN, whereas baseline renal function showed no statistically significant relationship to DN. The duration of DM was not associated with the presence of DN. Patients with DN had a higher rate of diabetic retinopathy (DR) than those with non-DN (DN 18 patients vs non-DN three patients, P = 0.00029). DN patients with DR showed a more severe renal histology than those without.

CONCLUSIONS: These data suggest that, even for patients with long-term DM, renal biopsy should be carried out in patients with presumed DN. Because treatment options differ between DN and primary glomerulopathies, renal biopsy should especially be considered for presumed DN without DR.

Keywords: Diabetic nephropathy; Diagnostic rate; Renal biopsy

References

  1. Nephrol Dial Transplant. 1998 Oct;13(10):2547-52 - PubMed
  2. J Assoc Physicians India. 2001 Apr;49:415-20 - PubMed
  3. Nephrol Dial Transplant. 2008 Jun;23(6):1940-5 - PubMed
  4. Medicine (Baltimore). 1959 Dec;38:321-67 - PubMed
  5. J Diabetes Investig. 2010 Oct 19;1(5):212-28 - PubMed
  6. J Am Soc Nephrol. 1993 Feb;3(8):1458-66 - PubMed
  7. Intern Med. 2001 Nov;40(11):1077-84 - PubMed
  8. Kidney Int. 1992 Apr;41(4):758-62 - PubMed
  9. Diabetologia. 1996 Dec;39(12):1638-45 - PubMed
  10. N Engl J Med. 1993 Sep 30;329(14):977-86 - PubMed
  11. Ophthalmology. 1991 May;98(5 Suppl):786-806 - PubMed
  12. Diabetologia. 2001 Oct;44(10):1215-20 - PubMed
  13. Yonsei Med J. 1999 Aug;40(4):321-6 - PubMed
  14. Clin Nephrol. 2007 May;67(5):293-7 - PubMed
  15. Diabetes Res Clin Pract. 2005 Sep;69(3):237-42 - PubMed
  16. Diabetes Res Clin Pract. 2007 Nov;78(2):189-95 - PubMed
  17. Kidney Int. 2000 Oct;58(4):1719-31 - PubMed
  18. Diabetes. 1975 Jan;24(1):1-9 - PubMed

Publication Types