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Chew RJ, Teo KY, Huang Y, et al. Enantioselective phospha-Michael addition of diarylphosphines to β,γ-unsaturated α-ketoesters and amides. Chem Commun (Camb). 2014;50(63):8768-70doi: 10.1039/c4cc01610f.
Chew, R. J., Teo, K. Y., Huang, Y., Li, B. B., Li, Y., Pullarkat, S. A., & Leung, P. H. (2014). Enantioselective phospha-Michael addition of diarylphosphines to β,γ-unsaturated α-ketoesters and amides. Chemical communications (Cambridge, England), 50(63), 8768-70. https://doi.org/10.1039/c4cc01610f
Chew, Renta Jonathan, et al. "Enantioselective phospha-Michael addition of diarylphosphines to β,γ-unsaturated α-ketoesters and amides." Chemical communications (Cambridge, England) vol. 50,63 (2014): 8768-70. doi: https://doi.org/10.1039/c4cc01610f
Chew RJ, Teo KY, Huang Y, Li BB, Li Y, Pullarkat SA, Leung PH. Enantioselective phospha-Michael addition of diarylphosphines to β,γ-unsaturated α-ketoesters and amides. Chem Commun (Camb). 2014 Aug 14;50(63):8768-70. doi: 10.1039/c4cc01610f. Epub 2014 Jun 26. PMID: 24968261.
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Chem Commun (Camb). 2014 Aug 14;50(63):8768-70. doi: 10.1039/c4cc01610f. Epub 2014 Jun 26.

Enantioselective phospha-Michael addition of diarylphosphines to β,γ-unsaturated α-ketoesters and amides.

Chemical communications (Cambridge, England)

Renta Jonathan Chew, Kai Yuan Teo, Yinhua Huang, Bin-Bin Li, Yongxin Li, Sumod A Pullarkat, Pak-Hing Leung

Affiliations

  1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. [email protected].

PMID: 24968261 DOI: 10.1039/c4cc01610f

Abstract

An enantioselective hydrophosphination of β,γ-unsaturated α-ketoesters and amides has been developed using a chiral palladacycle catalyst. Adducts can be obtained in excellent yields and enantioselectivities, providing direct access to chiral tertiary phosphines which are synthetically useful intermediates in the preparation of bidentate ligands.

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