Display options
Cite
Wan JP, Lin Y, Huang Q, et al. Diastereoselective construction of tetrahydropyridine fused bicyclic structures via three-component domino reaction. J Org Chem. 2014;79(15):7232-8doi: 10.1021/jo501292q.
Wan, J. P., Lin, Y., Huang, Q., & Liu, Y. (2014). Diastereoselective construction of tetrahydropyridine fused bicyclic structures via three-component domino reaction. The Journal of organic chemistry, 79(15), 7232-8. https://doi.org/10.1021/jo501292q
Wan, Jie-Ping, et al. "Diastereoselective construction of tetrahydropyridine fused bicyclic structures via three-component domino reaction." The Journal of organic chemistry vol. 79,15 (2014): 7232-8. doi: https://doi.org/10.1021/jo501292q
Wan JP, Lin Y, Huang Q, Liu Y. Diastereoselective construction of tetrahydropyridine fused bicyclic structures via three-component domino reaction. J Org Chem. 2014 Aug 01;79(15):7232-8. doi: 10.1021/jo501292q. Epub 2014 Jul 15. PMID: 25003698.
Copy Download .nbib Format: NLM
Share it on

J Org Chem. 2014 Aug 01;79(15):7232-8. doi: 10.1021/jo501292q. Epub 2014 Jul 15.

Diastereoselective construction of tetrahydropyridine fused bicyclic structures via three-component domino reaction.

The Journal of organic chemistry

Jie-Ping Wan, Yunfang Lin, Qing Huang, Yunyun Liu

Affiliations

  1. College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, PR China.

PMID: 25003698 DOI: 10.1021/jo501292q

Abstract

The three-component reactions of enals, electron-deficient alkynes, and hydroxyl-functionalized primary amines for the highly diastereoselective construction of dihydro-3H-benzo[4,5]oxazolo[3,2-a]pyridines, hexahydropyrido[2,1-b][1,3]oxazines, and tetrahydro-2H-oxazolo[3,2-a]pyridines have been achieved. Domino formation of one C-C, two C-N, and one C-O bonds are furnished in these reactions. This bis-annulation protocol allows for the synthesis of fused heterocyclic products of high structural diversity with variation not only of appended fragments but also the ring size of the central backbone.

Publication Types