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Li Y, Wongsiriroj N, Blaner WS. The multifaceted nature of retinoid transport and metabolism. Hepatobiliary Surg Nutr. 2014;3(3):126-39doi: 10.3978/j.issn.2304-3881.2014.05.04.
Li, Y., Wongsiriroj, N., & Blaner, W. S. (2014). The multifaceted nature of retinoid transport and metabolism. Hepatobiliary surgery and nutrition, 3(3), 126-39. https://doi.org/10.3978/j.issn.2304-3881.2014.05.04
Li, Yang, et al. "The multifaceted nature of retinoid transport and metabolism." Hepatobiliary surgery and nutrition vol. 3,3 (2014): 126-39. doi: https://doi.org/10.3978/j.issn.2304-3881.2014.05.04
Li Y, Wongsiriroj N, Blaner WS. The multifaceted nature of retinoid transport and metabolism. Hepatobiliary Surg Nutr. 2014 Jun;3(3):126-39. doi: 10.3978/j.issn.2304-3881.2014.05.04. PMID: 25019074; PMCID: PMC4073323.
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Hepatobiliary Surg Nutr. 2014 Jun;3(3):126-39. doi: 10.3978/j.issn.2304-3881.2014.05.04.

The multifaceted nature of retinoid transport and metabolism.

Hepatobiliary surgery and nutrition

Yang Li, Nuttaporn Wongsiriroj, William S Blaner

Affiliations

  1. 1 Columbia College, Columbia University, New York, NY, USA ; 2 Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand ; 3 College of Physicians and Surgeons, Columbia University, New York, NY, USA.

PMID: 25019074 PMCID: PMC4073323 DOI: 10.3978/j.issn.2304-3881.2014.05.04

Abstract

Since their discovery over a century ago, retinoids have been the most studied of the fat-soluble vitamins. Unlike most vitamins, retinoids are stored at relatively high concentrations in the body to buffer against nutritional insufficiency. Until recently, it was thought that the sole important retinoid delivery pathway to tissues involved retinol bound to retinol-binding protein (RBP4). More recent findings, however, indicate that retinoids can be delivered to tissues through multiple overlapping delivery pathways, involving chylomicrons, very low density lipoprotein (VLDL) and low density lipoprotein (LDL), retinoic acid bound to albumin, water soluble β-glucuronides of retinol and retinoic acid, and provitamin A carotenoids. This review will focus on explaining this evolving understanding of retinoid metabolism and transport within the body.

Keywords: Vitamin A; beta-carotene; hypervitaminosis A; hypovitaminosis A; metabolic disease; retinol-binding protein (RBP4); transthyretin (TTR)

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