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Sorwell KG, Kohama SG, Urbanski HF. Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque. Front Endocrinol (Lausanne). 2014;5:101doi: 10.3389/fendo.2014.00101.
Sorwell, K. G., Kohama, S. G., & Urbanski, H. F. (2014). Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque. Frontiers in endocrinology, 5101. https://doi.org/10.3389/fendo.2014.00101
Sorwell, Krystina G, et al. "Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque." Frontiers in endocrinology vol. 5 (2014): 101. doi: https://doi.org/10.3389/fendo.2014.00101
Sorwell KG, Kohama SG, Urbanski HF. Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque. Front Endocrinol (Lausanne). 2014 Jun 25;5:101. doi: 10.3389/fendo.2014.00101. eCollection 2014. PMID: 25009533; PMCID: PMC4070064.
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Front Endocrinol (Lausanne). 2014 Jun 25;5:101. doi: 10.3389/fendo.2014.00101. eCollection 2014.

Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque.

Frontiers in endocrinology

Krystina G Sorwell, Steven G Kohama, Henryk F Urbanski

Affiliations

  1. Division of Neuroscience, Oregon National Primate Research Center , Beaverton, OR , USA ; Department of Behavioral Neuroscience, Oregon Health & Sciences University , Portland, OR , USA.
  2. Division of Neuroscience, Oregon National Primate Research Center , Beaverton, OR , USA.
  3. Division of Neuroscience, Oregon National Primate Research Center , Beaverton, OR , USA ; Department of Behavioral Neuroscience, Oregon Health & Sciences University , Portland, OR , USA ; Department of Physiology and Pharmacology, Oregon Health & Sciences University , Portland, OR , USA ; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center , Beaverton, OR , USA.

PMID: 25009533 PMCID: PMC4070064 DOI: 10.3389/fendo.2014.00101

Abstract

The adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are two of the most abundant hormones in the human circulation. Furthermore, they are released in a circadian pattern and show a marked age-associated decline. Adult levels of DHEA and DHEAS are significantly higher in males than in females, but the reason for this sexual dimorphism is unclear. In the present study, we administered supplementary androgens [DHEA, testosterone and 5α-dihydrotestosterone (DHT)] to aged male rhesus macaques (Macaca mulatta). While this paradigm increased circulating DHEAS immediately after DHEA administration, an increase was also observed following either testosterone or DHT administration, resulting in hormonal profiles resembling levels observed in young males in terms of both amplitude and circadian pattern. This stimulatory effect was limited to DHEAS, as an increase in circulating cortisol was not observed. Taken together, these data demonstrate an influence of the hypothalamo-pituitary-testicular axis on adrenal function in males, possibly by sensitizing the zona reticularis to the stimulating action of adrenocorticopic hormone. This represents a plausible mechanism to explain sex differences in circulating DHEA and DHEAS levels, and may have important implications in the development of hormone therapies designed for elderly men and women.

Keywords: adrenal gland; aging; androgen; dehydroepiandrosterone; non-human primate; testosterone

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