Display options
Cite
Maldonado JO, Martin JL, Mueller JD, et al. New insights into retroviral Gag-Gag and Gag-membrane interactions. Front Microbiol. 2014;5:302doi: 10.3389/fmicb.2014.00302.
Maldonado, J. O., Martin, J. L., Mueller, J. D., Zhang, W., & Mansky, L. M. (2014). New insights into retroviral Gag-Gag and Gag-membrane interactions. Frontiers in microbiology, 5302. https://doi.org/10.3389/fmicb.2014.00302
Maldonado, José O, et al. "New insights into retroviral Gag-Gag and Gag-membrane interactions." Frontiers in microbiology vol. 5 (2014): 302. doi: https://doi.org/10.3389/fmicb.2014.00302
Maldonado JO, Martin JL, Mueller JD, Zhang W, Mansky LM. New insights into retroviral Gag-Gag and Gag-membrane interactions. Front Microbiol. 2014 Jun 24;5:302. doi: 10.3389/fmicb.2014.00302. eCollection 2014. PMID: 25009535; PMCID: PMC4068372.
Copy Download .nbib Format: NLM
Share it on

Front Microbiol. 2014 Jun 24;5:302. doi: 10.3389/fmicb.2014.00302. eCollection 2014.

New insights into retroviral Gag-Gag and Gag-membrane interactions.

Frontiers in microbiology

José O Maldonado, Jessica L Martin, Joachim D Mueller, Wei Zhang, Louis M Mansky

Affiliations

  1. 1Institute for Molecular Virology, University of Minnesota Minneapolis, MN, USA ; 2Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota , Minneapolis, MN, USA.
  2. 1Institute for Molecular Virology, University of Minnesota Minneapolis, MN, USA ; 3Pharmacology Graduate Program, University of Minnesota Minneapolis, MN, USA.
  3. 1Institute for Molecular Virology, University of Minnesota Minneapolis, MN, USA ; 4School of Physics and Astronomy, University of Minnesota Minneapolis, MN, USA.
  4. 1Institute for Molecular Virology, University of Minnesota Minneapolis, MN, USA ; 2Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota , Minneapolis, MN, USA ; 5Characterization Facility, University of Minnesota Minneapolis, MN, USA.
  5. 1Institute for Molecular Virology, University of Minnesota Minneapolis, MN, USA ; 2Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota , Minneapolis, MN, USA ; 3Pharmacology Graduate Program, University of Minnesota Minneapolis, MN, USA ; 6Department of Microbiology, University of Minnesota Minneapolis, MN, USA.

PMID: 25009535 PMCID: PMC4068372 DOI: 10.3389/fmicb.2014.00302

Abstract

A critical aspect of viral replication is the assembly of virus particles, which are subsequently released as progeny virus. While a great deal of attention has been focused on better understanding this phase of the viral life cycle, many aspects of the molecular details remain poorly understood. This is certainly true for retroviruses, including that of the human immunodeficiency virus type 1 (HIV-1; a lentivirus) as well as for human T-cell leukemia virus type 1 (HTLV-1; a deltaretrovirus). This review discusses the retroviral Gag protein and its interactions with itself, the plasma membrane and the role of lipids in targeting Gag to virus assembly sites. Recent progress using sophisticated biophysical approaches to investigate - in a comparative manner - retroviral Gag-Gag and Gag-membrane interactions are discussed. Differences among retroviruses in Gag-Gag and Gag-membrane interactions imply dissimilar molecular aspects of the viral assembly pathway, including the interactions of Gag with lipids at the membrane.

Keywords: deltaretrovirus; lentivirus; multimerization; oligomerization; plasma membrane; spectroscopy

References

  1. J Virol. 2002 Apr;76(8):4131-7 - PubMed
  2. J Virol. 1995 Jun;69(6):3407-19 - PubMed
  3. Physiol Rev. 2008 Jul;88(3):1089-118 - PubMed
  4. Trends Biochem Sci. 2011 Jul;36(7):373-80 - PubMed
  5. J Virol. 1994 Dec;68(12):8180-7 - PubMed
  6. J Mol Biol. 2014 Apr 3;426(7):1611-24 - PubMed
  7. J Virol. 2010 Jan;84(1):503-15 - PubMed
  8. J Cell Biol. 2003 Aug 4;162(3):443-55 - PubMed
  9. J Virol. 2004 Sep;78(17):9560-3 - PubMed
  10. J Virol. 2013 Mar;87(6):3609-15 - PubMed
  11. J Virol. 2011 Oct;85(20):10851-60 - PubMed
  12. FEBS Lett. 2007 May 22;581(11):2089-97 - PubMed
  13. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19114-9 - PubMed
  14. J Virol. 1999 Aug;73(8):7050-5 - PubMed
  15. Science. 1997 Oct 31;278(5339):849-53 - PubMed
  16. Structure. 2005 Oct;13(10):1521-31 - PubMed
  17. J Virol. 2005 Nov;79(21):13463-72 - PubMed
  18. PLoS Pathog. 2010 Nov 18;6(11):e1001200 - PubMed
  19. Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24 - PubMed
  20. Cell Microbiol. 2013 May;15(5):809-22 - PubMed
  21. J Virol. 2004 Nov;78(22):12378-85 - PubMed
  22. J Virol. 2001 Sep;75(17):7913-24 - PubMed
  23. J Virol. 2001 Jun;75(11):5277-87 - PubMed
  24. Virus Res. 2013 Feb;171(2):341-5 - PubMed
  25. J Mol Biol. 2011 Jul 22;410(4):512-24 - PubMed
  26. Cell Host Microbe. 2008 Nov 13;4(5):495-504 - PubMed
  27. Future Virol. 2009;4(3):241-257 - PubMed
  28. Biophys J. 2009 Mar 4;96(5):1961-9 - PubMed
  29. J Virol. 2012 Apr;86(8):4182-93 - PubMed
  30. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):517-22 - PubMed
  31. Biophys J. 2011 Mar 16;100(6):1587-95 - PubMed
  32. Curr Opin Immunol. 2007 Aug;19(4):402-7 - PubMed
  33. Proc Natl Acad Sci U S A. 1990 Jan;87(2):523-7 - PubMed
  34. FEBS Lett. 2009 Apr 17;583(8):1243-50 - PubMed
  35. J Virol. 2011 Mar;85(5):2304-15 - PubMed
  36. J Virol. 2009 Jul;83(14):7322-36 - PubMed
  37. J Virol. 2012 Dec;86(23):12991-6 - PubMed
  38. J Virol. 2000 Jun;74(12):5395-402 - PubMed
  39. Science. 1999 Jan 1;283(5398):80-3 - PubMed
  40. Science. 2008 Feb 15;319(5865):921-6 - PubMed
  41. J Virol. 2007 Sep;81(17):8977-88 - PubMed
  42. J Virol. 1998 Nov;72(11):9313-7 - PubMed
  43. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8420-4 - PubMed
  44. J Virol. 2007 Jul;81(14):7476-90 - PubMed
  45. Biochem Soc Trans. 2009 Oct;37(Pt 5):955-60 - PubMed
  46. Traffic. 2002 Oct;3(10):718-29 - PubMed
  47. J Virol. 1992 Apr;66(4):1856-65 - PubMed
  48. Traffic. 2003 Dec;4(12):902-10 - PubMed
  49. Biochim Biophys Acta. 1999 Aug 12;1451(1):1-16 - PubMed
  50. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):417-8 - PubMed
  51. J Virol. 2008 Mar;82(5):2405-17 - PubMed
  52. Curr Med Chem. 2013;20(1):4-21 - PubMed
  53. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14889-94 - PubMed
  54. J Virol. 2007 Jun;81(12):6434-45 - PubMed
  55. Nat Struct Mol Biol. 2004 Jul;11(7):672-5 - PubMed
  56. Curr Top Microbiol Immunol. 1985;115:221-33 - PubMed
  57. J Biol Chem. 2010 Jan 1;285(1):295-307 - PubMed
  58. J Virol. 2000 Mar;74(6):2855-66 - PubMed
  59. J Virol. 2000 Apr;74(7):3046-57 - PubMed
  60. J Virol. 1996 Dec;70(12):8540-8 - PubMed
  61. J Virol. 2005 Dec;79(23):14498-506 - PubMed
  62. PLoS Biol. 2006 Dec;4(12):e435 - PubMed
  63. J Mol Biol. 2011 Feb 18;406(2):205-14 - PubMed
  64. Cell. 2008 Oct 3;135(1):49-60 - PubMed
  65. J Virol. 2011 Apr;85(8):3802-10 - PubMed
  66. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18761-6 - PubMed
  67. J Virol. 2007 Dec;81(23):12899-910 - PubMed
  68. RNA. 2001 Apr;7(4):576-84 - PubMed
  69. J Mol Biol. 2011 Jul 22;410(4):491-500 - PubMed
  70. Cell. 2003 Feb 21;112(4):467-80 - PubMed
  71. J Virol. 2003 May;77(9):5439-50 - PubMed
  72. J Virol. 1994 Apr;68(4):2556-69 - PubMed
  73. Eur J Immunol. 2003 Feb;33(2):483-93 - PubMed
  74. J Mol Biol. 2007 Jan 19;365(3):799-811 - PubMed
  75. PLoS Pathog. 2008 Mar 07;4(3):e1000015 - PubMed
  76. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7299-304 - PubMed
  77. Jpn J Cancer Res. 1985 Dec;76(12):1132-5 - PubMed

Publication Types

Grant support