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Park JS, Park HC, Choi DH, et al. Prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases. Radiat Oncol J. 2014;32(2):77-83doi: 10.3857/roj.2014.32.2.77.
Park, J. S., Park, H. C., Choi, D. H., Park, W., Yu, J. I., Park, Y. S., Kang, W. K., & Park, J. O. (2014). Prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases. Radiation oncology journal, 32(2), 77-83. https://doi.org/10.3857/roj.2014.32.2.77
Park, Jun Su, et al. "Prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases." Radiation oncology journal vol. 32,2 (2014): 77-83. doi: https://doi.org/10.3857/roj.2014.32.2.77
Park JS, Park HC, Choi DH, Park W, Yu JI, Park YS, Kang WK, Park JO. Prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases. Radiat Oncol J. 2014 Jun;32(2):77-83. doi: 10.3857/roj.2014.32.2.77. Epub 2014 Jun 30. PMID: 25061576; PMCID: PMC4104223.
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Radiat Oncol J. 2014 Jun;32(2):77-83. doi: 10.3857/roj.2014.32.2.77. Epub 2014 Jun 30.

Prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases.

Radiation oncology journal

Jun Su Park, Hee Chul Park, Doo Ho Choi, Won Park, Jeong Il Yu, Young Suk Park, Won Ki Kang, Joon Oh Park

Affiliations

  1. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  2. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

PMID: 25061576 PMCID: PMC4104223 DOI: 10.3857/roj.2014.32.2.77

Abstract

PURPOSE: To determine the prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases.

MATERIALS AND METHODS: Sixteen patients received whole liver radiotherapy (WLRT) between January 1997 and June 2013. A total dose of 21 Gy was delivered in 7 fractions.

RESULTS: The median survival time after WLRT was 9 weeks. In univariate analysis, performance status, serum albumin and total bilirubin level, liver volume and extrahepatic metastases were associated with survival. The mean liver volume was significantly different between subgroups with and without pain relief (3,097 and 4,739 mL, respectively; p = 0.002).

CONCLUSION: A larger liver volume is a poor prognostic factor for survival and also a negative predictive factor for response to WLRT. If patients who are referred for WLRT have large liver volume, they should be informed of the poor prognosis and should be closely observed during and after WLRT.

Keywords: Colorectal cancer; Liver; Metastasis; Radiotherapy; Tumor burden

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