J Am Podiatr Med Assoc. 2014 Sep-Oct;104(5):455-67. doi: 10.7547/0003-0538-104.5.455.
Journal of the American Podiatric Medical Association
Paul Beeson
PMID: 25275733 DOI: 10.7547/0003-0538-104.5.455
BACKGROUND: Posterior tibial tendinopathy (PTT) is the most common cause of acquired (progressive) flatfoot deformity in adults. To date, PTT research has mainly focused on management rather than on causal mechanisms. The etiology of PTT is likely to be multifactorial because both intrinsic and extrinsic risk factors have been reported. We sought to critically evaluate reported etiologic factors for PTT and consider the concept of genetic risk factors.
METHODS: A detailed review of the literature published after 1936 was undertaken using English-language medical databases.
RESULTS: No clear consensus exists as to the relative importance of the risk factors reported, and neither has any consideration been given to a possible genetic basis for PTT.
CONCLUSIONS: To date, studies have examined various intrinsic and extrinsic risk factors implicated in the etiology of PTT. The interaction of these factors with an individual's genetic background may provide valuable data and help offer a more complete risk profile for PTT. A properly constructed genetic association study to determine the genetic basis of PTT would provide a novel and alternative approach to understanding this condition.
