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Schmidt MF. Drug target miRNAs: chances and challenges. Trends Biotechnol. 2014;32(11):578-585doi: 10.1016/j.tibtech.2014.09.002.
Schmidt, M. F. (2014). Drug target miRNAs: chances and challenges. Trends in biotechnology, 32(11), 578-585. https://doi.org/10.1016/j.tibtech.2014.09.002
Schmidt, Marco F. "Drug target miRNAs: chances and challenges." Trends in biotechnology vol. 32,11 (2014): 578-585. doi: https://doi.org/10.1016/j.tibtech.2014.09.002
Schmidt MF. Drug target miRNAs: chances and challenges. Trends Biotechnol. 2014 Nov;32(11):578-585. doi: 10.1016/j.tibtech.2014.09.002. Epub 2014 Oct 08. PMID: 25304465.
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Trends Biotechnol. 2014 Nov;32(11):578-585. doi: 10.1016/j.tibtech.2014.09.002. Epub 2014 Oct 08.

Drug target miRNAs: chances and challenges.

Trends in biotechnology

Marco F Schmidt

Affiliations

  1. University Chemical Laboratory, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. Electronic address: [email protected].

PMID: 25304465 DOI: 10.1016/j.tibtech.2014.09.002

Abstract

miRNAs, short ribonucleic acid gene regulators, are increasingly popular drug targets. Traditionally 'undruggable' proteins can be targeted via their miRNA gene regulators, enabling the treatment of diseases that, at present, seem impossible to cure. However, addressing miRNAs requires innovation at the level of drug discovery. This review article outlines the potential of miRNAs as drug targets, focuses on the challenges of developing miRNA-targeting drugs, and surveys new advances. The aim is to provide an orientation guide for scientists, as well business analysts, to help them navigate the jungle of different approaches in miRNA drug discovery.

Copyright © 2014 Elsevier Ltd. All rights reserved.

Keywords: RNAi; antisense agents; drug discovery; miRNA; miRNA-induced silencing complex; small molecule miRNA modulators

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