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Zoeller RT, Bergman Å, Becher G, et al. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health. 2014;13:118doi: 10.1186/1476-069X-13-118.
Zoeller, R. T., Bergman, �. �., Becher, G., Bjerregaard, P., Bornman, R., Brandt, I., Iguchi, T., Jobling, S., Kidd, K. A., Kortenkamp, A., Skakkebaek, N. E., Toppari, J., & Vandenberg, L. N. (2014). A path forward in the debate over health impacts of endocrine disrupting chemicals. Environmental health : a global access science source, 13118. https://doi.org/10.1186/1476-069X-13-118
Zoeller, R Thomas, et al. "A path forward in the debate over health impacts of endocrine disrupting chemicals." Environmental health : a global access science source vol. 13 (2014): 118. doi: https://doi.org/10.1186/1476-069X-13-118
Zoeller RT, Bergman Å, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek NE, Toppari J, Vandenberg LN. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health. 2014 Dec 22;13:118. doi: 10.1186/1476-069X-13-118. PMID: 25533907; PMCID: PMC4298083.
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Environ Health. 2014 Dec 22;13:118. doi: 10.1186/1476-069X-13-118.

A path forward in the debate over health impacts of endocrine disrupting chemicals.

Environmental health : a global access science source

R Thomas Zoeller, Åke Bergman, Georg Becher, Poul Bjerregaard, Riana Bornman, Ingvar Brandt, Taisen Iguchi, Susan Jobling, Karen A Kidd, Andreas Kortenkamp, Niels E Skakkebaek, Jorma Toppari, Laura N Vandenberg

Affiliations

  1. University of Massachusetts Amherst, Amherst, MA, USA. [email protected].

PMID: 25533907 PMCID: PMC4298083 DOI: 10.1186/1476-069X-13-118

Abstract

Several recent publications reflect debate on the issue of "endocrine disrupting chemicals" (EDCs), indicating that two seemingly mutually exclusive perspectives are being articulated separately and independently. Considering this, a group of scientists with expertise in basic science, medicine and risk assessment reviewed the various aspects of the debate to identify the most significant areas of dispute and to propose a path forward. We identified four areas of debate. The first is about the definitions for terms such as "endocrine disrupting chemical", "adverse effects", and "endocrine system". The second is focused on elements of hormone action including "potency", "endpoints", "timing", "dose" and "thresholds". The third addresses the information needed to establish sufficient evidence of harm. Finally, the fourth focuses on the need to develop and the characteristics of transparent, systematic methods to review the EDC literature. Herein we identify areas of general consensus and propose resolutions for these four areas that would allow the field to move beyond the current and, in our opinion, ineffective debate.

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