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Zhao Y, Xiong W, Wu X. A case of secondary pulmonary alveolar proteinosis, but prior to myelodysplastic syndrome. Respirol Case Rep. 2013;1(2):58-61doi: 10.1002/rcr2.29.
Zhao, Y., Xiong, W., & Wu, X. (2013). A case of secondary pulmonary alveolar proteinosis, but prior to myelodysplastic syndrome. Respirology case reports, 1(2), 58-61. https://doi.org/10.1002/rcr2.29
Zhao, Yunfeng, et al. "A case of secondary pulmonary alveolar proteinosis, but prior to myelodysplastic syndrome." Respirology case reports vol. 1,2 (2013): 58-61. doi: https://doi.org/10.1002/rcr2.29
Zhao Y, Xiong W, Wu X. A case of secondary pulmonary alveolar proteinosis, but prior to myelodysplastic syndrome. Respirol Case Rep. 2013 Dec;1(2):58-61. doi: 10.1002/rcr2.29. Epub 2013 Oct 31. PMID: 25473545; PMCID: PMC4184530.
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Respirol Case Rep. 2013 Dec;1(2):58-61. doi: 10.1002/rcr2.29. Epub 2013 Oct 31.

A case of secondary pulmonary alveolar proteinosis, but prior to myelodysplastic syndrome.

Respirology case reports

Yunfeng Zhao, Wei Xiong, Xueling Wu

Affiliations

  1. Department of Respiratory Disease, Shanghai Pudong New Area Gongli Hospital Shanghai, China.
  2. Institute of Respiratory Medicine, Xinqiao Hospital, Third Military Medical University Chongqing, China.

PMID: 25473545 PMCID: PMC4184530 DOI: 10.1002/rcr2.29

Abstract

Pulmonary alveolar proteinosis (PAP) is a rare lung disorder. We herein report the first case of PAP that happened 2 years before myelodysplatic syndrome (MDS). A 34-year-old Chinese presented with a developed recurrent cough and shortness of breath. Computed tomography scan disclosed ground-glass opacities with interlobular septal thickening. Histological examination showed eosinophilic dense homogenous material filling in the alveolar. This precipitate had a fine granular appearance. The eosinophilic material was periodic acid-Schiff reaction-positive. The patient was diagnosed with PAP. Two years later he was admitted to a hospital because of dizziness of 1-month duration. Hematological examination showed white blood cells was 2700, hemoglobin was 7.4 g/dL, and platelet count was 21,000 platelets/mm(3). Following bone marrow biopsy and histopathologic examination, he was diagnosed with MDS with refractory anemia and excess blasts. So for PAP patients, follow-up tests should be considered in order to find any possible underlying disease.

Keywords: Myelodysplastic syndrome; secondary pulmonary alveolar proteinosis

References

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