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Guo Y, Tihan T, Kim H, et al. Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Neuroimmunol Neuroinflamm. 2014;1(3):147-152doi: 10.4103/2347-8659.143674.
Guo, Y., Tihan, T., Kim, H., Hess, C., Lawton, M. T., Young, W. L., Zhao, Y., & Su, H. (2014). Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Neuroimmunology and neuroinflammation, 1(3), 147-152. https://doi.org/10.4103/2347-8659.143674
Guo, Yi, et al. "Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation." Neuroimmunology and neuroinflammation vol. 1,3 (2014): 147-152. doi: https://doi.org/10.4103/2347-8659.143674
Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao Y, Su H. Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation. Neuroimmunol Neuroinflamm. 2014;1(3):147-152. doi: 10.4103/2347-8659.143674. PMID: 25568888; PMCID: PMC4283567.
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Neuroimmunol Neuroinflamm. 2014;1(3):147-152. doi: 10.4103/2347-8659.143674.

Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation.

Neuroimmunology and neuroinflammation

Yi Guo, Tarik Tihan, Helen Kim, Christopher Hess, Michael T Lawton, William L Young, Yuanli Zhao, Hua Su

Affiliations

  1. Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA ; Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 071000 China.
  2. Department of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.
  3. Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
  4. Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94110, USA.
  5. Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110, USA.
  6. Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA ; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110, USA ; Department of Neurology, University of California, San Francisco, San Francisco, CA 94110, USA.
  7. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 410011, China.

PMID: 25568888 PMCID: PMC4283567 DOI: 10.4103/2347-8659.143674

Abstract

AIM: To test the hypothesis that lymphocyte infiltration in brain arteriovenous malformation (bAVM) is not associated with iron deposition (indicator of microhemorrhage).

METHODS: Sections of unruptured, previously untreated bAVM specimens (n=19) were stained immunohistochemically for T-lymphocytes (CD3

RESULTS: Both T lymphocytes and macrophages were present in unruptured, previously untreated bAVM specimens, whereas few B cells and plasma cells were detected. Iron deposition was detected in 8 specimens (42%; 95% confidence interval =20-67%). The samples with iron deposition tended to have more macrophages than those without (666±313 vs 478±174 cells/mm

CONCLUSIONS: T-lymphocytes were present in bAVM specimens. Unlike macrophages, the load and location of T-lymphocytes were not associated with iron deposition, suggesting the possibility of an independent cell-mediated immunological mechanism in bAVM pathogenesis.

Keywords: B-lymphocyte; T-lymphocyte; human brain arteriovenous malformation; inflammatory cells; microhemorrhage

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