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Thomas S, Ranganathan D, Francis L, et al. Current concepts in C3 glomerulopathy. Indian J Nephrol. 2014;24(6):339-48doi: 10.4103/0971-4065.134089.
Thomas, S., Ranganathan, D., Francis, L., Madhan, K., & John, G. T. (2014). Current concepts in C3 glomerulopathy. Indian journal of nephrology, 24(6), 339-48. https://doi.org/10.4103/0971-4065.134089
Thomas, S, et al. "Current concepts in C3 glomerulopathy." Indian journal of nephrology vol. 24,6 (2014): 339-48. doi: https://doi.org/10.4103/0971-4065.134089
Thomas S, Ranganathan D, Francis L, Madhan K, John GT. Current concepts in C3 glomerulopathy. Indian J Nephrol. 2014 Nov;24(6):339-48. doi: 10.4103/0971-4065.134089. PMID: 25484526; PMCID: PMC4244712.
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Indian J Nephrol. 2014 Nov;24(6):339-48. doi: 10.4103/0971-4065.134089.

Current concepts in C3 glomerulopathy.

Indian journal of nephrology

S Thomas, D Ranganathan, L Francis, K Madhan, G T John

Affiliations

  1. Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.
  2. Department of Pathology, Royal Brisbane and Women's Hospital, Brisbane, Australia.
  3. Department of Renal Medicine, Hervey Bay Hospital, Hervey Bay, Australia.

PMID: 25484526 PMCID: PMC4244712 DOI: 10.4103/0971-4065.134089

Abstract

Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising of dense deposit disease and C3 glomerulonephritis. The key histological feature is the presence of isolated C3 deposits without immunoglobulins. Often masqueradng as some of the common glomerulonephritides this is a prototype disorder occurring from dysregulated alternate complement pathway with recently identified genetic defects and autoantibodies. We review the pathophysiology, clinical features, and diagnostic and treatment strategies.

Keywords: Alternate complement pathway; complement component 3 glomerulonephritis; complement component 3 glomerulopathy; complements; dense deposit disease

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