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Weasner BP, Anderson J, Kumar JP. The Eye Specification Network in Drosophila. Proc Indian Natl Sci Acad B Biol Sci. 2004;(5):517-530
Weasner, B. P., Anderson, J., & Kumar, J. P. (2004). The Eye Specification Network in Drosophila. Proceedings of the Indian National Science Academy. Part B, Biological sciences, (5), 517-530.
Weasner, Brandon P, et al. "The Eye Specification Network in Drosophila." Proceedings of the Indian National Science Academy. Part B, Biological sciences vol. ,5 (2004): 517-530.
Weasner BP, Anderson J, Kumar JP. The Eye Specification Network in Drosophila. Proc Indian Natl Sci Acad B Biol Sci. 2004;(5):517-530. PMID: 25580038; PMCID: PMC4286332.
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Proc Indian Natl Sci Acad B Biol Sci. 2004;(5):517-530.

The Eye Specification Network in Drosophila.

Proceedings of the Indian National Science Academy. Part B, Biological sciences

Brandon P Weasner, Jason Anderson, Justin P Kumar

Affiliations

  1. Department of Biology,Indiana University1001 E. 3rd StreetBloomington, IN 47401.

PMID: 25580038 PMCID: PMC4286332

Abstract

One of the most exciting revelations in retinal biology is the realization that the molecules and mechanisms that regulate eye development have been conserved in all seeing animals including such diverse organisms as the fruit fly, mouse and man. The emerging commonality among mechanisms used in eye development allows for the use of model systems such as the fruit fly, Drosophila melanogaster, to provide key insights into the development and diseases of the mammalian eye. Eye specification in Drosophila is controlled, in part, by the concerted activities of eight nuclear proteins and several signal transduction cascades that together form a tightly woven regulatory network. Loss of function mutations in several components lead to the complete derailment of eye development while ectopic expression of threse genes in non-retinal tissues can direct the fates of these tissues towards eye formation. Here we will describe what is currently known about this remarkable regulatory cassettee highlight some of the outstanding questions that still need to be answered.

Keywords: Eye specification; Fly eye; Master regulators; Patterning pathways function

References

  1. Cell. 2001 Mar 9;104(5):687-97 - PubMed
  2. Development. 2002 Sep;129(18):4271-80 - PubMed
  3. Science. 1995 Mar 24;267(5205):1788-92 - PubMed
  4. JAMA. 1992 Mar 18;267(11):1524-31 - PubMed
  5. Development. 1994 Dec;120(12):3473-86 - PubMed
  6. Development. 2003 Jul;130(13):3053-62 - PubMed
  7. Genet Res. 1971 Jun;17(3):195-208 - PubMed
  8. Development. 1997 Feb;124(4):817-25 - PubMed
  9. Dev Biol. 2003 Jun 1;258(1):117-28 - PubMed
  10. Mech Dev. 2001 May;103(1-2):71-8 - PubMed
  11. Proc Natl Sci Counc Repub China B. 2000 Apr;24(2):47-55 - PubMed
  12. Development. 2002 Dec;129(23 ):5377-88 - PubMed
  13. Semin Cell Dev Biol. 2001 Dec;12 (6):469-74 - PubMed
  14. Br J Ophthalmol. 1999 Jun;83(6):723-7 - PubMed
  15. Development. 1991 Nov;113(3):841-50 - PubMed
  16. Nature. 1995 Feb 23;373(6516):709-11 - PubMed
  17. Genes Dev. 1998 Feb 1;12(3):435-46 - PubMed
  18. Gene. 2002 Feb 20;285(1-2):221-8 - PubMed
  19. J Muscle Res Cell Motil. 2002;23 (3):255-64 - PubMed
  20. Development. 1998 Jul;125(14 ):2701-10 - PubMed
  21. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7331-5 - PubMed
  22. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2421-6 - PubMed
  23. Development. 2003 Sep;130(18):4473-82 - PubMed
  24. Ophthalmic Genet. 1999 Mar;20(1):7-21 - PubMed
  25. Development. 1998 Nov;125(21):4163-74 - PubMed
  26. Development. 1995 Jul;121(7):2117-25 - PubMed
  27. Dev Biol. 2004 Aug 1;272(1):231-47 - PubMed
  28. Annu Rev Neurosci. 1997;20:483-532 - PubMed
  29. Cell. 1995 Jun 30;81(7):987-90 - PubMed
  30. Development. 2004 Aug;131(16):3943-53 - PubMed
  31. Mol Med. 2002 Oct;8(10):607-11 - PubMed
  32. Trends Genet. 1999 Sep;15(9):371-7 - PubMed
  33. Curr Top Dev Biol. 1998;39:119-58 - PubMed
  34. Development. 1997 Jan;124(2):559-67 - PubMed
  35. Development. 1999 May;126(10):2253-60 - PubMed
  36. Genet Res. 1970 Feb;15(1):29-34 - PubMed
  37. Development. 2002 Jun;129(12):2835-49 - PubMed
  38. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2140-4 - PubMed
  39. Hum Mol Genet. 2000 Feb 12;9(3):363-6 - PubMed
  40. Development. 2000 Aug;127(16):3475-88 - PubMed
  41. Int J Dev Biol. 2002 Jan;46(1):65-73 - PubMed
  42. Dev Biol. 2001 Apr 15;232(2):315-26 - PubMed
  43. Development. 2004 Feb;131(3):551-62 - PubMed
  44. Development. 2002 Feb;129(4):1075-82 - PubMed
  45. Genome Res. 1997 Feb;7(2):128-41 - PubMed
  46. Cell. 1997 Dec 26;91(7):893-903 - PubMed
  47. Mech Dev. 1999 May;83(1-2):127-39 - PubMed
  48. Dev Biol. 2000 May 15;221(2):355-64 - PubMed
  49. Bioessays. 1999 Oct;21(10):843-50 - PubMed
  50. Development. 1999 Feb;126(5):935-43 - PubMed
  51. Mech Dev. 2002 Feb;111(1-2):75-87 - PubMed
  52. Trends Neurosci. 1989 Mar;12(3):102-10 - PubMed
  53. Nature. 1991 Dec 19-26;354(6354):522-5 - PubMed
  54. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2117-22 - PubMed
  55. Nature. 2003 Nov 20;426(6964):295-8 - PubMed
  56. Curr Opin Genet Dev. 1995 Oct;5(5):602-9 - PubMed
  57. Cell. 1997 Dec 26;91(7):881-91 - PubMed
  58. Development. 2003 Jan;130(1):185-95 - PubMed
  59. Development. 1995 Nov;121(11):3519-27 - PubMed
  60. Cell. 1991 Dec 20;67(6):1059-74 - PubMed
  61. EMBO J. 2001 Feb 15;20(4):802-11 - PubMed
  62. Nat Genet. 2004 Jan;36(1):31-9 - PubMed
  63. Development. 2003 Sep;130(17 ):3989-4000 - PubMed
  64. Nature. 2003 Nov 20;426(6964):299-302 - PubMed
  65. Pediatr Nephrol. 2004 Mar;19(3):249-55 - PubMed
  66. Development. 2002 Feb;129(4):1015-26 - PubMed
  67. Genes Dev. 2002 Sep 15;16(18):2415-27 - PubMed
  68. Nat Genet. 1999 Sep;23 (1):113-7 - PubMed
  69. Hum Mol Genet. 2001 Nov 15;10(24):2775-81 - PubMed
  70. Development. 2000 Mar;127(6):1325-36 - PubMed
  71. Exp Nephrol. 2002;10(2):102-13 - PubMed
  72. Int J Dev Biol. 1999 Sep;43(6):501-8 - PubMed
  73. Cell. 1993 Dec 3;75(5):927-38 - PubMed
  74. Dev Biol. 1987 Apr;120(2):366-76 - PubMed
  75. Mech Dev. 2000 Aug;96(1):15-25 - PubMed
  76. Dev Genes Evol. 2001 Sep;211(8-9):406-14 - PubMed
  77. Bioessays. 2000 Jul;22(7):616-26 - PubMed
  78. Development. 2002 Feb;129(3):625-34 - PubMed
  79. Nature. 1998 Jul 9;394(6689):196-200 - PubMed
  80. Bioessays. 2004 Jun;26(6):600-3 - PubMed
  81. Mech Dev. 2001 Apr;102(1-2):169-79 - PubMed
  82. Genes Cells. 1996 Jan;1(1):11-5 - PubMed
  83. Dev Biol. 1976 Oct 15;53(2):217-40 - PubMed
  84. Nat Rev Genet. 2001 Nov;2(11):846-57 - PubMed
  85. Gene. 2000 May 16;249(1-2):1-16 - PubMed
  86. Mech Dev. 2003 Oct;120(10 ):1113-26 - PubMed
  87. Dev Cell. 2001 Jul;1(1):51-61 - PubMed
  88. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2020-5 - PubMed
  89. Development. 2000 May;127(9):1879-86 - PubMed
  90. Dev Biol. 1989 Dec;136(2):346-62 - PubMed
  91. Mech Dev. 2003 Jun;120(6):669-79 - PubMed
  92. Nature. 1995 Sep 7;377(6544):52-5 - PubMed
  93. Neuron. 1994 May;12(5):977-96 - PubMed
  94. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2658-63 - PubMed
  95. Genes Dev. 1998 Jul 1;12(13):1931-40 - PubMed
  96. Development. 2003 May;130(10):2239-52 - PubMed
  97. Mol Cell Biol. 2003 Sep;23(17):5989-99 - PubMed
  98. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15508-12 - PubMed
  99. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14220-5 - PubMed
  100. Genet Res. 1969 Jun;13(3):313-20 - PubMed
  101. Development. 2002 Jul;129(13):3033-44 - PubMed
  102. J Neurobiol. 2001 Feb 5;46(2):73-88 - PubMed
  103. Dev Dyn. 2004 Jan;229(1):162-75 - PubMed
  104. Mech Dev. 1998 Oct;77(2):185-96 - PubMed
  105. Mol Cell. 1999 Mar;3(3):297-307 - PubMed
  106. Cell. 1993 Dec 3;75(5):913-26 - PubMed
  107. Development. 2001 Feb;128(4):491-502 - PubMed
  108. J Biol Chem. 2001 Jun 1;276(22):19033-9 - PubMed
  109. Dev Biol. 1987 Sep;123(1):264-75 - PubMed
  110. Nature. 2003 Nov 20;426(6964):247-54 - PubMed
  111. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):558-63 - PubMed
  112. Development. 2003 Jul;130(13):2939-51 - PubMed
  113. Genes Dev. 1999 Dec 15;13(24):3231-43 - PubMed
  114. Dev Genes Evol. 2001 Mar;211(3):138-44 - PubMed
  115. Genes Dev. 1994 Feb 15;8(4):399-413 - PubMed
  116. Mol Cell Neurosci. 1996;8(1):14-27 - PubMed
  117. Cell. 1993 Feb 12;72(3):379-95 - PubMed
  118. Development. 1998 Jun;125(12):2181-91 - PubMed
  119. Mol Cell Biol. 2004 Jul;24(14):6253-67 - PubMed
  120. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4024-9 - PubMed
  121. Proc Biol Sci. 1994 Apr 22;256(1345):53-8 - PubMed
  122. Genetics. 1994 Dec;138(4):1137-50 - PubMed
  123. Development. 2003 Dec;130(25):6351-60 - PubMed
  124. Genes Dev. 1997 Aug 15;11(16):2023-8 - PubMed
  125. Dev Biol. 2003 Apr 1;256(1):49-60 - PubMed
  126. Genes Dev. 1997 May 1;11(9):1122-31 - PubMed
  127. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8090-5 - PubMed
  128. Development. 1997 Jan;124(2):271-8 - PubMed
  129. Development. 2003 Jul;130(14):3085-94 - PubMed
  130. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23 ):13720-5 - PubMed
  131. Genes Dev. 1997 Dec 1;11(23):3254-64 - PubMed
  132. Genes Dev. 2001 Jul 1;15(13):1716-23 - PubMed
  133. Mech Dev. 1998 May;73(2):193-202 - PubMed
  134. Mol Cell Biol. 2002 Oct;22(19):6759-66 - PubMed
  135. Dev Biol. 1998 Apr 1;196(1):42-57 - PubMed
  136. Dev Biol. 1998 May 15;197(2):187-97 - PubMed
  137. Semin Cell Dev Biol. 2001 Dec;12(6):475-84 - PubMed
  138. Science. 1994 Aug 5;265(5173):785-9 - PubMed
  139. Development. 1997 Jan;124(1):219-31 - PubMed
  140. Development. 1997 Dec;124(23):4819-26 - PubMed

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