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Acosta MA, Jiang X, Huang PK, et al. A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia. Biomicrofluidics. 2014;8(5):054117doi: 10.1063/1.4898788.
Acosta, M. A., Jiang, X., Huang, P. K., Cutler, K. B., Grant, C. S., Walker, G. M., & Gamcsik, M. P. (2014). A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia. Biomicrofluidics, 8(5), 054117. https://doi.org/10.1063/1.4898788
Acosta, Miguel A, et al. "A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia." Biomicrofluidics vol. 8,5 (2014): 054117. doi: https://doi.org/10.1063/1.4898788
Acosta MA, Jiang X, Huang PK, Cutler KB, Grant CS, Walker GM, Gamcsik MP. A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia. Biomicrofluidics. 2014 Oct 17;8(5):054117. doi: 10.1063/1.4898788. eCollection 2014 Sep. PMID: 25584114; PMCID: PMC4290574.
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Biomicrofluidics. 2014 Oct 17;8(5):054117. doi: 10.1063/1.4898788. eCollection 2014 Sep.

A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia.

Biomicrofluidics

Miguel A Acosta, Xiao Jiang, Pin-Kang Huang, Kyle B Cutler, Christine S Grant, Glenn M Walker, Michael P Gamcsik

Affiliations

  1. UNC/NCSU Joint Department of Biomedical Engineering, North Carolina State University , 4206D Engineering Building III, 911 Oval Drive, Raleigh, North Carolina 27695-7115, USA.
  2. Department of Chemical Engineering, National Taiwan University of Science and Technology , No. 43, Sec. 4, Keelung Road, Da'an District, Taipei City 106, Taiwan.
  3. Department of Biomedical Engineering, Beckman Laser Institute, University of California Irvine , 1002 Health Services Road, Irvine, California 92617, USA.

PMID: 25584114 PMCID: PMC4290574 DOI: 10.1063/1.4898788

Abstract

Metastatic cancer cells must traverse a microenvironment ranging from extremely hypoxic, within the tumor, to highly oxygenated, within the host's vasculature. Tumor hypoxia can be further characterized by regions of both chronic and intermittent hypoxia. We present the design and characterization of a microfluidic device that can simultaneously mimic the oxygenation conditions observed within the tumor and model the cell migration and intravasation processes. This device can generate spatial oxygen gradients of chronic hypoxia and produce dynamically changing hypoxic microenvironments in long-term culture of cancer cells.

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