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Davydova E, Deridder S, Eeltink S, et al. Optimization and evaluation of radially interconnected versus bifurcating flow distributors using computational fluid dynamics modelling. J Chromatogr A. 2014;1380:88-95doi: 10.1016/j.chroma.2014.12.063.
Davydova, E., Deridder, S., Eeltink, S., Desmet, G., & Schoenmakers, P. J. (2015). Optimization and evaluation of radially interconnected versus bifurcating flow distributors using computational fluid dynamics modelling. Journal of chromatography. A, 138088-95. https://doi.org/10.1016/j.chroma.2014.12.063
Davydova, E, et al. "Optimization and evaluation of radially interconnected versus bifurcating flow distributors using computational fluid dynamics modelling." Journal of chromatography. A vol. 1380 (2015): 88-95. doi: https://doi.org/10.1016/j.chroma.2014.12.063
Davydova E, Deridder S, Eeltink S, Desmet G, Schoenmakers PJ. Optimization and evaluation of radially interconnected versus bifurcating flow distributors using computational fluid dynamics modelling. J Chromatogr A. 2015 Feb 06;1380:88-95. doi: 10.1016/j.chroma.2014.12.063. Epub 2014 Dec 30. PMID: 25591402.
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J Chromatogr A. 2015 Feb 06;1380:88-95. doi: 10.1016/j.chroma.2014.12.063. Epub 2014 Dec 30.

Optimization and evaluation of radially interconnected versus bifurcating flow distributors using computational fluid dynamics modelling.

Journal of chromatography. A

E Davydova, S Deridder, S Eeltink, G Desmet, P J Schoenmakers

Affiliations

  1. Analytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, PO Box 94157, 1090 GD Amsterdam, The Netherlands. Electronic address: [email protected].
  2. Vrije Universiteit Brussel (VUB), Department of Chemical Engineering, 1050 Brussels, Belgium.
  3. Analytical Chemistry Group, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, PO Box 94157, 1090 GD Amsterdam, The Netherlands.

PMID: 25591402 DOI: 10.1016/j.chroma.2014.12.063

Abstract

Two main groups of flow distributors, viz. "bifurcating distributors" (BF) and "radially interconnected distributors" (RI), as well as some hybrid distributors were investigated. Computational fluid dynamics was used to evaluate the performance of the distributors and to establish the design yielding the most uniform velocity field and the smallest variance for the bands emerging from the distributor. A minimum channel width of 100 μm was considered to allow the use of micro-milling techniques for chip fabrication. The main factors that influenced the values of band variances were identified. The performance of the distributors was found to correlate most strongly with the volume of the flow distributors. The separation bed should be positioned immediately after, but not against the flow distributor. It was concluded that BF distributors perform best in terms of band variance. The values of band variances for the BF distributor decreased with increasing angle between bifurcation branches and the lowest value of about 0.01 mm(2) was found for α=175°. Both BF and RI flow distributors were found to perform reasonably well when imperfections were present in the structure. However, severe blockages (exceeding 75% of the cross-sectional area and length) of channels in, especially, BF flow distributors may jeopardize their performance.

Copyright © 2015 Elsevier B.V. All rights reserved.

Keywords: Chip-based separations; Computational fluid dynamics; Flow distributors; Microfluidics; Robust performance

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