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Su S, Tang M, Zhang M, et al. The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males. Meta Gene. 2013;1:58-64doi: 10.1016/j.mgene.2013.09.005.
Su, S., Tang, M., Zhang, M., Cheng, C., & Tang, X. (2013). The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males. Meta gene, 158-64. https://doi.org/10.1016/j.mgene.2013.09.005
Su, Shu, et al. "The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males." Meta gene vol. 1 (2013): 58-64. doi: https://doi.org/10.1016/j.mgene.2013.09.005
Su S, Tang M, Zhang M, Cheng C, Tang X. The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males. Meta Gene. 2013 Nov 15;1:58-64. doi: 10.1016/j.mgene.2013.09.005. eCollection 2013 Dec. PMID: 25606375; PMCID: PMC4205029.
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Meta Gene. 2013 Nov 15;1:58-64. doi: 10.1016/j.mgene.2013.09.005. eCollection 2013 Dec.

The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males.

Meta gene

Shu Su, Min Tang, Mingjun Zhang, Chunquan Cheng, Xiaojun Tang

Affiliations

  1. School of Public Health and Management, Chongqing Medical University, Chongqing, China ; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
  2. College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
  3. The First People's Hospital of Jiulongpo District, Chongqing, China.
  4. Chonggang Hospital, Chongqing, China.
  5. School of Public Health and Management, Chongqing Medical University, Chongqing, China.

PMID: 25606375 PMCID: PMC4205029 DOI: 10.1016/j.mgene.2013.09.005

Abstract

BACKGROUND: Although apolipoprotein (apo) CIII gene polymorphisms have proved to be related to the increased serum lipid level in foreign studies, the results have not always been consistent among diverse populations. In addition, the research focuses on the impact of the apoCIII on the serum lipid levels of Han Chinese subjects which was not conducted before.

OBJECTIVE: To explore the relationship between the apoCIII gene C3175G and T3206G polymorphisms and serum lipid levels as well as other risk factors for hyperlipidaemia, in Han Chinese males.

METHOD: A total of 337 healthy male participants undergoing physical examinations were randomly selected from two hospitals in Chongqing, China. Through DNA sequencing, apoCIII gene C3175G and T3206G polymorphisms were identified and their relationships with serum lipid levels were further analysed.

RESULTS: Carriers of apoCIII(3175) GG genotypes have higher levels of TG than other genotypes (P < 0.05). After the stratified selection of triacylglycerol (TG), G gene loci of apoCIIIT3206G are associated with decreasing the content of total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) in relatively high TG group while the G gene loci of apoCIIIC3175G have an inverse effect. The outcome of TG unconditional logistic regression shows that the G gene loci of apoCIIIT3206G polymorphism are also beneficial for decreasing TG.

CONCLUSION: The detection of TG in apoCIII(3175) GG genotype carriers is an efficient predictor of hypertriglyceridaemia in Han Chinese males. The G gene loci of apoCIII(3206) may be beneficial for decreasing serum lipid level.

Keywords: ANOVA, Analysis of variance; ApoCIII gene; ApoCIII, Apolipoprotein CIII; BMI, Physique index; HDL-C, High density lipoprotein-cholesterol; HTG, Hypertriglyceridaemia; IR, Insulin resistance; LDL-C, Low density lipoprotein-cholesterol; Polymorphism; Serum lipids; TC, Total cholesterol; TG, Triacylglycerol; TRL, Triglyceride-rich lipoprotein; WHR, Waist to hip ratio

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