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Gong XG, Sun HM, Zhang Y, et al. Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evid Based Complement Alternat Med. 2014;2014:729195doi: 10.1155/2014/729195.
Gong, X. G., Sun, H. M., Zhang, Y., Zhang, S. J., Gao, Y. S., Feng, J., Hu, J. H., Gai, C., Guo, Z. Y., Xu, H., & Ma, L. (2014). Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evidence-based complementary and alternative medicine : eCAM, 2014729195. https://doi.org/10.1155/2014/729195
Gong, Xiao-Gang, et al. "Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease." Evidence-based complementary and alternative medicine : eCAM vol. 2014 (2014): 729195. doi: https://doi.org/10.1155/2014/729195
Gong XG, Sun HM, Zhang Y, Zhang SJ, Gao YS, Feng J, Hu JH, Gai C, Guo ZY, Xu H, Ma L. Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evid Based Complement Alternat Med. 2014;2014:729195. doi: 10.1155/2014/729195. Epub 2014 Dec 24. PMID: 25610480; PMCID: PMC4290155.
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Evid Based Complement Alternat Med. 2014;2014:729195. doi: 10.1155/2014/729195. Epub 2014 Dec 24.

Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease.

Evidence-based complementary and alternative medicine : eCAM

Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling Ma

Affiliations

  1. Department of Anatomy, School of Preclinical Medicine, Beijing University of Chinese Medicine, No. 11 N. 3rd Ring Eastern Road, Beijing 100029, China.
  2. Center of Scientific Research, School of Preclinical Medicine, Beijing University of Chinese Medicine, No. 11 N. 3rd Ring Eastern Road, Beijing 100029, China.

PMID: 25610480 PMCID: PMC4290155 DOI: 10.1155/2014/729195

Abstract

Da-Bu-Yin-Wan (DBYW) and Qian-Zheng-San (QZS), two classic traditional Chinese medicinal formulas, were clinically employed to treat Parkinson's disease (PD). Our previous studies demonstrated neuroprotective effects of them on mitochondrial function in PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The purpose of this research was to investigate their possible mechanisms in the light of mitochondrial ATP-sensitive potassium (mitoKATP) channels. The neuroprotective effect of DBYW and QZS on dopamine (DA) neurons in substantia nigra (SN) in the MPTP-induced PD mice was investigated by behavioral test (pole test) and immunohistochemistry. Adenosine triphosphate (ATP) level in the midbrain tissue was detected by firefly luciferase method. MitoKATP channel subunits SUR1 and Kir6.2 mRNA and protein expressions were tested by real-time PCR (RT-PCR) and Western blot. It was observed that DBYW and/or QZS served to ameliorate MPTP-induced behavioral impairment and prevent the loss of substantia nigra dopamine neurons, as well as increase ATP level in the midbrain tissue and downregulate SUR1 expression at mRNA and protein levels with no marked influence on Kir6.2. We concluded that DBYW and QZS exhibit neuroprotective effects probably through the regulation of ATP level and mitoKATP channel subunit expressions.

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