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Serpooshan V, Mahmoudi M. Micropatterned nanostructures: a bioengineered approach to mass-produce functional myocardial grafts. Nanotechnology. 2015;26(6):060501doi: 10.1088/0957-4484/26/6/060501.
Serpooshan, V., & Mahmoudi, M. (2015). Micropatterned nanostructures: a bioengineered approach to mass-produce functional myocardial grafts. Nanotechnology, 26(6), 060501. https://doi.org/10.1088/0957-4484/26/6/060501
Serpooshan, Vahid, and Mahmoudi, Morteza. "Micropatterned nanostructures: a bioengineered approach to mass-produce functional myocardial grafts." Nanotechnology vol. 26,6 (2015): 060501. doi: https://doi.org/10.1088/0957-4484/26/6/060501
Serpooshan V, Mahmoudi M. Micropatterned nanostructures: a bioengineered approach to mass-produce functional myocardial grafts. Nanotechnology. 2015 Feb 13;26(6):060501. doi: 10.1088/0957-4484/26/6/060501. Epub 2015 Jan 22. PMID: 25611345.
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Nanotechnology. 2015 Feb 13;26(6):060501. doi: 10.1088/0957-4484/26/6/060501. Epub 2015 Jan 22.

Micropatterned nanostructures: a bioengineered approach to mass-produce functional myocardial grafts.

Nanotechnology

Vahid Serpooshan, Morteza Mahmoudi

Affiliations

  1. Stanford Cardiovascular Institute, Stanford, CA, 94305 USA.

PMID: 25611345 DOI: 10.1088/0957-4484/26/6/060501

Abstract

Cell-based therapies are a recently established path for treating a wide range of human disease. Tissue engineering of contractile heart muscle for replacement therapy is among the most exciting and important of these efforts. However, current in vitro techniques of cultivating functional mature cardiac grafts have only been moderately successful due to the poor capability of traditional two-dimensional cell culture systems to recapitulate necessary in vivo conditions. In this issue, Kiefer et al introduce a laser-patterned nanostructured substrate (Al/Al2O3 nanowires) for efficient maintenance of oriented human cardiomyocytes, with great potential to open new roads to mass-production of contractile myocardial grafts for cardiovascular tissue engineering.

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